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Proud of Carlijn Hoekx who gave a great flash talk at #DAS2023 on her recent paper in Cell Reports Medicine showing that hunan #BAT is activated by #ADRB2 rather than #ADRB3! 😊👍 Dutch Atherosclerosis Society LUMC Leiden

It has been great organizing a lipid session with Patricia Aspichueta at #EASL2023! Already looking forward to next year’s edition! 😊👍

Just published: a novel pharmacological approach to block #nash development by specifically activating LXRa in macrophages. Proud of Enchen ! 😊👍 embopress.org/doi/full/10.15…

Combined #GIP and #GLP1 receptor agonism additively attenuate #NAFLD development. Proud of Zhixiong and Robin! 😊👍 LUMC Leiden Eli Lilly and Company sciencedirect.com/science/articl…

Today Robin van Eenige defended his thesis ‘Targeting adipose tissue to improve cardiometabolic health’ with flying colors! All six experimental chapters, mainly supervised by @KooijmanSander have been published. Very proud promotor! 😊 LUMC Leiden

.LUMC Leiden researchers and collaborators show that inhibition of DHCR24 decreases liver #collagen content and plasma alanine transaminase levels in an established #NAFLD model. 🔓 #OpenAccess at EMBO Mol. Medicine bit.ly/46kjCW9

Today Huub van Eyk defended his thesis ‘GLP-1 receptor agonism to improve cardiometabolic health’, also with flying colors! Proud promotor! 😊🎉🎈 LUMC Leiden

Pharmacological inhibition of DHCR24 prevents #nash development by increasing the endogenous #lxr agonist #desmosterol! LUMC Leiden #patentpending 👇 lumc.nl/en/about-lumc/…

Highly recommended PhD position with a dedicated supervisor in Almería, and with the opportunity to perform part of the research at LUMC Leiden! 😊👍

Proud of @KooijmanSander who was awarded a Dekker Senior Scientist grant of the Dutch Heart Foundation to dive deeper into the #circadianrhythmn of #brownfat to reveal novel (chrono)therapeutic approaches to comBAT atherosclerotic #CVD! 😊👍 #batman LUMC Leiden 👇

Proud of Milena Schönke who just received an #EFSD grant to study the molecular mechanisms by which late #exercise via the #gut #microbiome improves #NAFLD! LUMC Leiden 👇

CETP Inhibition may well have therapeutic applications beyond targeting ASCVD, including protection against septicemia. Certainly relevant, giving that the bulk of circulating #CETP derives from #macrophages! LUMC Leiden NewAmsterdam Pharma Corporation sciencedirect.com/science/articl…

#CETP inhibition enhances bacterial clearance to reduce pneumoniae-associated mortality in APOE*3-Leiden.CETP mice, suggesting CETP inhibitors to be repurposed to prevent #sepsis-related mortality in humans! LUMC Leiden insight.jci.org/articles/view/…

Afterparty op treinstation Malmö #eurovision #esf #ESC2024 #Netherlands #Europapa

51 weeks a year a devoted scientist, one week a year absolutely not 😉🎉🎈🇳🇱

Just published in ATVB. Kudos to Frank Schaftenaar!

It was a real pleasure to give a keynote on (pre)clinical studies on #brownadiposetissue #bat at the annual meeting of the Austrian Atherosclerosis Society. Thank you so much for the kind invite! LUMC Leiden

Just online: Liver-targeted Angptl4 silencing attenuates hyperlipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice, our well-established model for human-like lipid metabolism and cardiometabolic diseases LUMC Leiden Lipigon Pharmaceuticals academic.oup.com/cardiovascres/…

Great paper of the Gerhart-Hines group just appeared in nature! 😊👍 Happy to have been modestly involved!

Guoli Li, Sijing Dong, Chunhao Liu, Jing Yang, Patrick C N Rensen, Yanan Wang academic.oup.com/lifemeta/artic…