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A rabbi, priest, guru and imam meet to resolve the outstanding questions & problems facing the worlds great religions. Remarkably they find good agreement and a unifying path forward. As they are leaving one of them asks "How do you think metformin works?" academic.oup.com/edrv/advance-a…

Biased agonism at nociceptin/orphanin FQ receptors: a structure activity study on N/OFQ(1-13)-NH2. zpr.io/HNM5s J Med Chem #GPCR #signaling #pharmacology

Back to School in Efforts to Interrogate Cell Surface Expression Recruitment of Arrestin to the GIP Receptor frontiersin.org/article/10.338…

#gpcr meeting FREE to academics 9th GDR meeting November 6th-9th, 2020 gdr3545.com/index.php/news…

“Water is a very strange liquid. But everybody’s familiar with it, so we don’t really realize how weird it is.” sciencenews.org/article/stop-m…

Have a look at our 2020 Series on the use of #CRISPR technology in #CellBiology. #NobelPrize2020 go.nature.com/2YaVMcF

“New data challenges the textbook physiology of both GLP-1 and glucagon and presents a critical paradigm shift for the field” via @DarleenSandoval diabetes.diabetesjournals.org/content/69/11/…

β-Coronaviruses traffic from ER to de-acidified lysosomes to leave cells. This also impairs antigen presentation. lnkd.in/dqNkvsm

Different GPCR isoforms have unique signaling outcomes/ bias and combinations could affect therapy nature.com/articles/s4158…

Need computational support for your project? We have a range of open source and commercial software tools for image analysis. Check out our website for contact details bit.ly/38q9Xlf #imageanalysis #microscopy

Is Gq activation the GLP-1 (vs. GIP) β cell secret sauce? "A Gs/Gq signaling switch in β cells exposed to chronic hyperglycemia underlies the differential insulinotropic potential of incretins #diabetes " Journal of Clinical Investigation jci.org/articles/view/…

Challenging the Selective Hepatic #Insulin Resistance Paradigm #NAFLF #NASH care.diabetesjournals.org/content/early/…

Is the induction of ER stress helpful or harmful in development of and adaptation to cardiometabolic diseases? The latest perspectives-New from #EndocrineReviews academic.oup.com/edrv/advance-a…

Excited to share our latest work on "small molecule drug discovery" published in "EJMC", where I am the co-corresponding author. Many thanks and Congratulations to my collaborators Dr. Kailash Singh, co-authors & Prof. BKC Chow. sciencedirect.com/science/articl…

Can we alter glucagon receptor signaling outcomes by changing it’s localization within the cell? Yes, we can! Let me explain how (and why that matters). (1/7) Revathi Sekar @kmotzler Helmholtz Diabetes Center (HDC) Helmholtz Munich | @HelmholtzMunich Cell Metabolism Cell Press tinyurl.com/y5fbu2bc

cell.com/cell-metabolis…

A contribution of endosomal signaling to GCGR localization and metabolic diseases that could be exploited for treatments of type 2 #diabetes Anja Zeigerer Cell Metabolism cell.com/cell-metabolis…

Congratulations/credits first!✅ Molecular detail/experimental depth obvious - even for non-experts👏🏻🎉 Commendable note re clinical cause-consequence? that rather elevates this complex study; opens crucial therapeutic opportunities👍🏻 Great effort! Helmholtz Diabetes Center (HDC) Anja Zeigerer

New nature The largest study of impact of dietary restriction (DR) in ~1,000 mice with diverse genetic background for health and lifespan nature.com/articles/s4158… —40% caloric restriction had the most lifespan expansion effect but suppressed immune response and loss of lean