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How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

After 7 years, thrilled to finally share our #MICrONS functional connectomics results! We recorded activity from ~75K neurons in visual cortex in a single mouse, then mapped its wiring using electron microscopy. To systematically characterize neuron function, we built the first

🌊 I can't believe it's only 10 days away! Our 6th Conference on the Mathematics of #Neuroscience and #AI in #Split, #Croatia! The team has put together a quite unheard of line-up, with many of the original and emerging pioneers in these two influential disciplines. And,

We will likely be looking for someone with expertise with optical methods in vivo, cranial window surgeries in mice, analysis of 2P imaging data (especially ML-based), viral approaches. Nothing posted yet, but I know there are good people looking, so please reach out.

In this mesmerizing video by our #ElectronMicroscopy team, a layer 5 thin tufted neuron is revealed with blue dendrites and purple axon. As it progresses, we zoom into where the neuron connects to a pyramidal cell. Made from our free MICrONS dataset: microns-explorer.org