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Congratulations @DS8874945102 on your exciting new work examining the role of #senescence in #bonefracturehealing. Exciting to see such a nice study come out so early in your stay here at the Mayo Clinic ! biorxiv.org/content/10.110…

Super excited! The first ever side-by-side comparison of the cond KO of #RNF20 & #RNF40 in the intestinal epithelium. KO of either decreased #VDR expression & activity & decreased #H3K4me3 spreading into the gene body. ⁦Robyn Tailor⁩ ⁦CDD press⁩ nature.com/articles/s4141…

Happy to receive a Young Investigator Award ASBMR 2021 Mayo Clinic Endocrinology #agingresearch #SanDiego Mayo Clinic #ASBMR2021 Uni Göttingen

Very happy that our eLIFE paper is finally out: We demonstrate for the first time that senescent cells accumulate in the fracture callus. Their clearance improves bone healing. doi.org/10.7554/eLife.… eLife - the journal #khoslalab #bonehealing #fracture #mayo #orthotwitter Sundeep Khosla

I just looked back to the seven posters on the issue of "#senescent" of the #ASBMR2021 of which the majority was from the Mayo's, and was happily amazed by the high quality and important findings of all ...when you did not see them, do it now

Happy to share our latest work about CRP in primary hip arthroplasty: mdpi.com/1331618 #mdpijcm via JCM MDPI Here we develop an algorithm predicting an early infection after hip arthroplasty at day 5 with a sensitivity of 87.5% 🧐💪 #orthotwitter #surgery #CRP #infection

We linked aging to cancer on a single cell level: Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations 🧬🥼mdpi.com/1353560 #mdpicells #aging #Cancer Single Cell papers Papers 📊 Mayo Clinic

Senescence is more than just p16 and p21: We developed an in silico approach to reveal cells high in the SASP. SenMayo🧑‍🔬 biorxiv.org/content/10.110… #aging #senescence Mayo Clinic Single Cell Media Single Cell papers Sundeep Khosla Madison Doolittle

Inflammation in the gut is encoded by neurons in the brain go.nature.com/34tetPR

Interested in spatial omics? Plz check out our squidpy tool, bringing together omics & image analysis to enable a scalable description of spatial molecular data. Out today Nature Methods thx to Giovanni Palla, Hannah Spitzer & team! nature.com/articles/s4159… github.com/theislab/squid…

Check out our review in #EndocrineReviews: Fracture healing and how it is affected by endocrine diseases, aging, and cellular senescence: academic.oup.com/edrv/advance-a… #fracture #Healing #bonehealing #bone #aging #senescence Orthopedics Today Mayo Clinic Endocrinology Mayo Clinic Sundeep Khosla

Beautiful to witness every kind of Evolution. This one speaks directly to my scientific heart!

Doolittle et al. use a new ERαΔOcy mouse model to decipher the mechanism of ERα action in bone: Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice asbmr.onlinelibrary.wiley.com/doi/10.1002/jb… #bone #jbmr #estrogen Sundeep Khosla Madison Doolittle Japneet Kaur Megan Moore Weivoda

Do you want to detect senescent cells in your sequencing dataset? Or monitor your senolytic therapy? SenMayo can help you: rdcu.be/cTL9h Nature Communications #senescence #aging #research #SASP #Bioinformatics Next Generation Sequencing Sundeep Khosla Madison Doolittle Robyn Kosinsky @PassosLab

Awesome presentation by Sundeep Khosla on fracture healing and the impact of p21-driven cellular senescence at ASBMR #ASBMR2022,thanks to Madison Doolittle Japneet Kaur Robyn Kosinsky and the KhoslaLab #fracture #bonehealing #aging #senescence #science #research #bone Mayo Clinic

Ever wondered why some bones 🦴do not heal? We outline answers from basic research and the clinic: Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors mdpi.com/2058992

🚨In this month’s edition of Gastroenterology our group William Faubion Lab, shows how inhibitors of the epigenetic enzyme G9a can metabolic reprogram Tcells into Treg capable of controlling Intestinal Inflammation. Cell engineering & Epigenetic Modulation as potential novel #IBD txs

What happens if you remove senescent cells from bone locally as compared to systemic senolysis? Amazing work by Farr and the Khosla Lab: JCI - Local senolysis in aged mice only partially replicates the benefits of systemic senolysis jci.org/articles/view/… Journal of Clinical Investigation

An old bisphosphate friend may help to alleviate the burden of senescence: Samakkarnthai et al. demonstrate this in vitro and in vivo biorxiv.org/content/10.110… Parinya Samakkarnthai Mayo Clinic Sundeep Khosla Madison Doolittle Jad Sfeir Japneet Kaur Nathan LeBrasseur @aging #bone #aging

Check out our commentary on spatial transcriptomics published in Clinical and Translational Medicine (doi.org/10.1002/ctm2.1…) . This methods allows us to analyze gene expression patterns in a tissue sample while preserving spatial information