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What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. nature.com/articles/s4158… out now in nature with Henri Niskanen Denes Hnisz & team.

Online Now: Tumor neutrophils rewired from birth dlvr.it/TLBc2R

Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair). A rather important set of negative results indicating that isn't the case (though I imagine many will still try). nature.com/articles/s4146…

A single factor for safer cellular rejuvenation biorxiv.org/content/10.110…

Misuse of p-values is a prevalent issue in scientific research. P-values are often misunderstood and misapplied, leading to incorrect conclusions. A p-value measures the probability of obtaining results at least as extreme as the observed ones, assuming that the null hypothesis

YAP, a protein known to help #cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, highlighting the importance of mimicking tumour architecture to guide better drug strategies. elifesciences.org/reviewed-prepr…

Nature research paper: Metabolic adaptations direct cell fate during tissue regeneration go.nature.com/3FMlpe4

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. elifesciences.org/articles/93180…

If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments. biorxiv.org/content/10.110…

It’s finally out!!🥳 Check out our paper in Nature Materials on a new hybrid scaffold where we discover ECM-specific cues that regulate cardiac aging 🔗 nature.com/articles/s4156… This is the lab’s 1st research paper, led by my 1st Nus Bioeng PhD student 𝐀𝐯𝐞𝐫𝐲 𝐒𝐮𝐧🤩 Tweetorial👇

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates | Nature Cell Biology nature.com/articles/s4155…

There’s tons out there about fibroblast #mechanobiology in disease. In Confinement Mechanobiology Lab at MBI’s new review in APL Bioengineering, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between! pubs.aip.org/aip/apb/articl…

Nature Machine Intelligence Shalin Mehta Chan Zuckerberg Initiative Read the paper, led by Ziwen Liu & Eduardo 'Yoshi' Hirata, here ⤵️ czi.co/44ejLd8

Online Now! Hallmarks of stem cell aging dlvr.it/TLXcsM #stemcells

Spatial multi-omics reveals cell-type-specific nuclear compartments | Nature nature.com/articles/s4158…

DNA methylation protects cancer cells against senescence nature.com/articles/s4146…

Key numbers in cell biology Having a sense of scale helps to think more rigorously and realistically about biological systems.

Cell size varies by many orders of magnitude. The mechanisms that generate and maintain this extraordinary diversity of sizes remain incompletely understood.

1/ No, you do not always need single-cell RNA-seq. Here's why bulk RNA-seq might still be the smarter move for your experiment.

💥Check out our latest work in Nature Communications We identify a new target to impair DNA repair🧬inducing #senescence and #celldeath through synthetic lethality in combination with cancer therapy🧵 🔗Open access PDF: rdcu.be/euQkW