🔥And it’s out!🔥 Today, we report in Nature Genetics how chronic inflammation drives the selective expansion of TP53-mutant cells in the blood, leading to the development of a deadly type of leukemia. nature.com/articles/s4158…

I am truly excited to share our latest work about the upsides and pitfalls of base and prime editing in #Hematopoietic #stemcells. Thanks to Samuele Ferrari, the Luigi NALDINI and all the collaborators for the huge effort. @Telethonitalia Ospedale San Raffaele nature.com/articles/s4158…

Very happy and honored to present our work from my postdoc project in @DaanNoordermeer lab I2BC Paris-Saclay on CTCF clustering at TAD boundaries and the novel multi-contact 3C assay: Nano-C – now published Nature Communications. nature.com/articles/s4146…. A nice 🧵 written by Daan 👇

Today in bioRxiv, we introduce Click Editing - which combines DNA-dependent polymerases, HUH endonucleases, and RNA-programmable nickases for versatile human genome editing without double-strand breaks. Co-led with Joana Ferreira da Silva 🤝🧬 (1/15) biorxiv.org/content/10.110…

Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with Connor Tou. A 🧵 (1/14): biorxiv.org/content/10.110…

We’re excited to share our work developing a new gene editing approach that we’re calling #clickediting 🖱️✴️🧬. Click editors (CEs) utilize DNA-dependent polymerases to write bespoke edits into the genome. biorxiv.org/content/10.110… CGM at MGH MassGeneral News @MGH_RI Harvard Medical School

Zero-sum thinking is a key mindset that shapes how we view the world. Excited to share a new paper on the roots and consequences of Zero-sum thinking with Sahil Chinoy, Nathan Nunn Sandra.Sequeira. A summary thread🧵1/23 scholar.harvard.edu/files/stantche…

Threads like this one are what makes this platform worthwhile for me! Super interesting read on zero-sum thinking.

Today's Nobel is a reminder to focus on the work and not the journal. The key publications cited by the committee were published in Immunity, Molecular Therapy, and Nucleic Acids Research. Respectable journals, but not the Big 3. The discoveries are what's important, not a name.

🚨New preprint🚨Today, we're excited to share our latest study, "Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning" via bioRxiv! Gerald Schwank Krauthammer Lab Bas van Steensel lab UZH Science biorxiv.org/content/10.110… 🧵

Delighted to share that our work to develop a base editor-mediated genetic treatment for SMA is now published in Nature Biomedical Engineering 💉💉🧬🎉 Congrats 👏 to @Christiano_RRA who led this work & all co-authors CGM at MGH @MGH_RI MGH Neurology MGH Pathology Harvard Medical School 🧵 nature.com/articles/s4155…

Have you ever wondered which methods are out there to culture haematopoietic stem cells? Here we review progress and challenges facing the field today! exphem.org/article/S0301-… Wilkinson Group MRC WIMM #exphem #hsc

Heading home from #ASH23? 👩‍💼🌞🌮Stuck in a line at security or facing a long layover? ✈️In withdrawal from all the amazing science? 🧪🧬 Read our preprint from my PhD work University of Oxford MRC WIMM presented in the MPN session yesterday! bit.ly/47RS2jg 1/n

We tend to massively idealize our memories or imaginations of the past. The good old times never existed, except in our minds.

Pleased to share our latest preprint identifying a GTPase cascade that modulates regional Wnt signalling in the intestine: biorxiv.org/content/10.110…

SpRYgests now enabled via purified SpRY protein through New England Biolabs, available here: neb.com/en-us/products… Super cool to have this option 'live' now - congrats to Russell Walton Kathleen Christie Roman Doll & many others who contributed. Happy SpRYgesting 😃

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base