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On my way home from again a fantastic ERA - European Renal Association congress! Sharing a taxi with NDT & CKJ’s Caroline Vinck discovering all Twitter secrets 🥳! See you in Milan #ERA23 🤩!

Proud to announce the start of our #AGAINST-PLD study. Will study whether lowering estrogens with #leuprorelin decreases liver volume in young women with extreme #PLD.

𝗧𝗢𝗗𝗔𝗬: ISN-Nephrology Journal Club joint #NephTrials Discussion on "The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD" 🕒 3 pm CET Warm up for the chat ➡️ nephjc.com/news/master-tr… #NephTwitter

#NephTrials Please have also a look at our wonderful website Renal-Lifecycle.com It has all kinds of information (text, infographics, ppt's, video's etc). For doctors as well as for patients.

Welcome. Ready to take questions (if there are).

#NephTrials Remarkable thing is that SGLT2 inhibitors are supposed to work via proximal tubles. When you don't have many of these tubules anymore, why would they work? Post-hoc analyses, however, suggest they do even at low eGFR.

#NephTrials Most trials include either predialysis, or dialysis or transplant patients. These are the stages of the Renal Lifecycle. We include all 3 groups in our trial. When a predialysis patient reaches dialysis, they do not stop, but continue in the trial. Hence our name

#NephTrials This is an investigator initiated trial, funded by money left to us by a beneficiary that passed away. Great gift. Yet still limited. That's whe we designed our trial to be pragmatic (low in costs and effort)