🚨 Our lab just rewrote life‘s operating system! Together, we’ve built Syn57 - an E. coli with a synthetic genome running on a 57-codon genetic code! biorxiv.org/content/10.110… #SyntheticBiology #Syn57 #PhD #GeneticCode #GenomeEngineering #Biosecurity #FutureOfBiology

Happy to share our preprint on TEAD1 condensates. Surprisingly we found they are transcriptionally inactive storage sites on the pericentromeric heterochromatin biorxiv.org/content/10.110…

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity biorxiv.org/content/10.110…

Happy to share our latest paper appeared in the Journal of Colloid and Interface Science @ELSchemistry. Congrats to my PhD student, Jaspreet Kaur Jaspreet Kaur Thapar Institute of Engineering & Technology. Thanks to Anusandhan National Research Foundation & MoE STARS for supporting our research. Here's the link: doi.org/10.1016/j.jcis…

Happy to share our latest paper published in Science Advances Science Advances @AAAS. Congratulations to my incredible students, Sandeep Sandeep Kumar Rai, Roopali Roopali Khanna (joint-first author), Anusha Anusha Sarbahi & Ashish Ashish Joshi @IISERMohali. science.org/doi/10.1126/sc…

We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: biorxiv.org/cgi/content/sh…

Happy to share our recent paper in RSC Advances Royal Society of Chemistry from our collaborative effort with Dr. Maity Banibrata Maity Thapar Institute of Engineering & Technology Congratulations to our PhD student Mandeep Kaur Mandeep Kaur (She/ Her). Read our paper: pubs.rsc.org/en/content/art…

We're one, but we're not the same We get to carry each other, carry each other – U2

RNA codon expansion via programmable pseudouridine editing and decoding: nature.com/articles/s4158…

A feature in nature shows how tardigrades exist in a sweet spot for researchers and why neuroscientists are working to make them a model organism for studying how neural circuits work. go.nature.com/3TGVCan

Our latest publication: Probing Protease‐Mediated Decrease of Albumin‐Catalyzed Kemp Elimination: Potential Application as Biosensors ChemCatChem congrats Shikha Priyanka Ekta Shandilya from Department of Chemical Sciences IISER Mohali. Thanks Department of Biotechnology for funding. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cc…

By flipping an evolutionarily disabled genetic switch involved in Vitamin A metabolism, researchers in Science have enabled ear tissue regeneration in mice. Learn more: scim.ag/44muTVr

Huge congratulations to Alina Emelianova, Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!! pubs.acs.org/doi/full/10.10…

Another paper accepted from the lab in the Proceedings of the Indian National Science Academy. Our first contribution to an Indian journal. Harshita Agarwal Harshita started this as a side project that turned into a nice story!

Building a human ear on the back of the mouse, 3D printed bone regeneration scaffolds, and human liver-on-a-chip, were warm-ups for building a human endometrium in lab. Want a difficult problem that is the root of women's health? Study menstruation. 🧵news.mit.edu/2025/mit-launc…

Thrilled to share this new Adv. Sci. paper by Diana Tanase with Dino Osmanovic Roger Rubio Sánchez Layla Malouf and Elisa Franco. We demonstrate a modular approach to program internal phase separation in DNA condensates 1/n advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. nature.com/articles/s4146…

Happy to share final version of our work in eLife - the journal! We reveal how inhibiting the UFD-1-NPL-4 complex in C. elegans triggers an aberrant immune response, reducing pathogen load but ultimately compromising host survival. Alejandro Aballay, PhD Rajneesh Rao Dept. of Biological Sciences (DBS), IISER Mohali elifesciences.org/articles/94310

Hijacking a bacterial ABC transporter for genetic code expansion: nature.com/articles/s4158…

Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs. pnas.org/doi/10.1073/pn…