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New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30

And here's where it gets really interesting: rather than thinking of Pando as a single "individual", we should probably view it as a long-term evolving clonal population - similar to bacteria in @RELenski's Long Term Evolution Experiment (LTEE). 18/30

I want to try something new at #ASHG24 this year: I'm going to block some time on Friday afternoon to meet with any trainees who would be interested to chat on any topic.

I am looking for a postdoc to work in theoretical population genetics. We focus on theory and methods for inferring demographic histories and selection using modern and ancient genomic data. Come join our amazing community in Chicago. More info here: steinrueckenlab.uchicago.edu/files/2024/11/…

Heading to #ASHG24 and looking for a postdoc position? Interested in genetic epidemiology, specifically gene x environment in diverse pediatric cohorts? I'll be here all week so find me to talk about opportunities with myself and Priya Duggal at Johns Hopkins Genetic Epidemiology in Baltimore!

1/n New preprint alert! 🚨🧬✨ The question we asked; is the genetic architecture of a complex trait different at the extreme ends of the distribution (i.e. tails) or similar to that in the main part of the trait distribution? #ASHG2024 #ASHG24 --> check out poster 4051T! 🧵👇🏾

Hiring Eleanor would be like hiring a -senior- postdoc. Don't pass up this opportunity to convince her to work with you!

NBC News projects: Angela Alsobrooks (D) wins Maryland Senate. Earlier, Lisa Blunt Rochester won her Senate race in Delaware. That means — for the first time ever — the Senate is about to have two Black women serving at the same time.

For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?

Course content can be found here: stanford-genethics.github.io And their publication on the course can be found here: cell.com/cell-genomics/…

was truly so much fun chatting with two of my personal role models - thanks jp flores (he/him) for having us!!

In a new preprint led by Nikhil Milind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

Excited to have this out there! Comments are very welcome.

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies biorxiv.org/cgi/content/sh… #biorxiv_genomic

Have a little new piece in Nature Human Behaviour: "Ethics of genomic research on occupational status" nature.com/articles/s4156…

Super excited to share my first grad school paper! It was so much fun working on this collaborative project from day one as a rotation student in the Curtis lab! Such a joy to work on with Katie, Mangiante, Cristina, Christina Curtis and Jennifer Caswell-Jin & thanks to the lab!

New paper with Sarthak R. Mishra ! Maybe it will bring you some joy given all this (waves arms around). "Estimating recombination using only the allele frequency spectrum" 1/2 biorxiv.org/content/10.110…

In #GENETICS, Roshni Patel, @spence_jeffrey_, Jonathan Pritchard, and colleagues explored the use of conditional frequency spectra to study selection on complex traits that circumvent some of the limitations of #GWAS. From our new Biobanks Series, read more: bit.ly/4gXsc1x

I'm thrilled to share that I'll be joining the Department of Genetics at UGA as an Assistant Professor in January! UGA Genetics UGA