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Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C biorxiv.org/cgi/content/sh… #bioRxiv

We are coming off three days of outstanding discussions and collaboration to advance pre-clinical ALS research. Our biennial ALS Research Symposium brought together more than 100 early-career researchers from across the globe. Safe travels home, everyone! #livelikelousymposium

introducing the folding phase-check out our new opinion article in which we propose a protein folding function of the nuclear pore complex: sciencedirect.com/science/articl…

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/sh…

Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.

Looks like PPS Silent Surfactant, Progenta anionic acid labile surfactant (AALS) I, AALS II, cationic acid labile surfactant (CALS) I, and CALS II are not commercially available anymore.

If Nature and Science journals both agree on this, surely there is at least a 60% chance it is true. nature.com/articles/d4158…

Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in Molecular Cell doi.org/10.1016/j.molc…

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.