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New in JACC Journals #JACCimaging Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque jacc.org/doi/10.1016/j.… /thread

High lipoprotein(a) [(Lp(a)] is a genetically determined, important risk factor for cardiovascular disease that should be (but isn't) routinely measured (at least once). There are 5 drugs that look highly effective for markedly lowering levels in clinical trials. This new

On Friday we science, on Sunday we farm 🍎🫏🐓🌽

Excited to share our preprint on the integrated genomic model for coronary artery disease (CAD)🧬! We integrated 6 genetic drivers (PRS, FH, CHIP, LTL, ProPRS, MetPRS) to enhance risk prediction for CAD From Broad Institute MGH Cardiovascular Research Center and Chinese Academy of Science Thread🧵~

I'm thrilled to share our latest preprint on metabolic polygenic risk score🧬! We developed metabolic PRS using multi-ancestry GWAS of 22 metabolic traits from over 10 million people. w/ Alisa Chen, Yang Sui, Akl Fahed Patrick Ellinor Pradeep Natarajan, and more Thread🧵

What a privilege to work with this group! 🥂

One superstar at our lab holiday party and his only scientific interest is optimizing cuddles, treats, and toys! #FahedLab MGH Cardiovascular Research Center Broad Institute

A new year and a first lab meeting picture for the books MGH Cardiovascular Research Center Broad Institute Harvard Medical School Mass General Heart

🔥 Mini-Review: "Polygenic Risk Scores in Human Disease" by Dimitri Maamari, MD, Roukoz A. Karam, MD & Akl Fahed MGH Cardiovascular Research Center, Broad Institute #MedTwitter #PathTwitter #LabMedX 👉 buff.ly/3DRuhxN

The relationship of high polygenic risk scores to coronary artery disease disease for extent of atherosclerosis and presentation with heart attack/unstable angina jamanetwork.com/journals/jaman… JAMA Network Open Akl Fahed Kelvin Supriami Pradeep Natarajan Patrick Ellinor

Germline monogenic and polygenic risk are associated with acute coronary syndromes presentation, severity and burden of atherosclerosis, and risk of repeat angiogram, revascularization, and in-stent restenosis. @ozanunlumd ja.ma/42ogBEG

🧵1/ Last year, a thoughtful reply to our JAMA article sent me down a rabbit hole on CVD prevention. Should statins be prescribed less or more often? Available OTC? Added to the water supply?? Let’s talk trials, thresholds, and tradeoffs!

#ACC25 #CircSimPub E-alerts (EPN; e.g., emails & messages) improved early recognition, rates for aortic valve replacement (AVR) and survival time for severe and symptomatic aortic stenosis (AS) patients in a r... ahajrnls.org/3QVW0k4 #AHAJournals Roukoz A. Karam, MD Sammy Elmariah MD MPH

#DETECTAS study #LBCT #ACC25 🫀Unmet need to detect severe AS 🫀using electronic notification 🆚 UC when severe AS noted on echo with guideline rec provided 🫀endpoint of AVR in 1 y 🫀37% UC 🆚 47% notification had TAVR 🫀greater referral in notification arm 📎 Circulation

Sammy Elmariah MD MPH DETECT AS — electronic nudges increase appropriate AVR in severe AS Srinath Adusumalli, MD, MSHP, MBMI, FACC

New in Circulation #ahajournals, late-breaker at #ACC25 American College of Cardiology E-alerts to providers improved early recognition, referral, AVR rates, and survival for patients with severe & symptomatic AS in a clinical trial Mass General Brigham Sammy Elmariah MD MPH ahajrnls.org/3QVW0k4

A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS NEJM nejm.org/doi/full/10.10…

Our ability to predict a person's risk of heart disease keeps getting better, even among those previously considered at low risk by traditional clinical criteria Nature Medicine Ali Torkamani Scripps Research Scripps Research Translational Institute nature.com/articles/s4159…

Hot off the press in Nature Medicine!🎉 Our latest paper sheds light on an often-overlooked question: How much of the global iron deficiency (ID) burden is directly attributable to suboptimal diet? By disentangling dietary causes, we identified the portion of the burden that

#NYValves2025 DETECT AS presented by Sammy Elmariah Design: sciencedirect.com/science/articl… Conclusion: 🔹EPN improves rates of AVR & prolongs survival in patients with severe AS, w greater benefits in women 🔹Gender disparities in AS management were eliminated by EPN w comparable