Why Deep Mutational Learning matters, a story in two press releases: biorxiv.org/content/10.110…

Joseph Taft LSSI Reddy We also found structural evidence that higher-order network effects between the Omicron mutated sites may perturb the physical and chemical properties of the epitope surface for this mAb. biorxiv.org/content/10.110…

Highlighting our recent work from LSSI Reddy involving the construction of combinatorial RBD libraries that were used to infer and validate ACE2 binding and escape from clinically relevant mAbs. Moving towards in silico prediction of escape for emerging variants🤓

SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display dlvr.it/SHN3hx

Platypus intensifies..

Protein engineers work wonders with machine learning, but generating data remains a bottleneck. Computer vision & NLP use data augmentation, but we lack such techniques for proteins. To address this, we develop nucleotide augmentation (NTA). A thread 🧵1/5 biorxiv.org/content/10.110…

Very happy that our work on generative machine learning for antibody design is now out in mAbs tandfonline.com/doi/full/10.10…. All details are in the preprint thread below. The peer-reviewed version contains more controls and also more comparisons of synthetic and experimental data.

Evasion of neutralizing antibodies by Omicron sublineage BA.2.75 biorxiv.org/content/10.110…

Proud to share our *finally* accepted paper. It was a wild ride, but we finally got there on my last day at D-BSSE, ETH Zurich ETH Zürich. Couldn't ask for a better way to finish my time in the LSSI Reddy. cell.com/cell/fulltext/…

Update: Our deep mutational learning #DML paper on #SARSCoV2 profiling is now online at Cell! Now with more in-depth assessments of a greater number of antibodies! cell.com/cell/fulltext/…

Sone good news about the BA.2.75 variant, in case it gets legs: it's not more immune evasive than BA.5, has cross-immunity w/ BA.1/2, and is still sensitive to Evusheld and Bebtelovimab thelancet.com/journals/lanin… The Lancet Infectious Diseases Ben Murrell Tom Peacock Daniel Sheward & colleagues

Happy to share our recent manuscript from LSSI Reddy has been published in Cell! Great work by Joseph Taft & Cédric R Weber et al. Moving towards predicting immune escape of future viral variants🤓

Fantastic new tool developed by the team of Sai Reddy LSSI Reddy: "#MachineLearning could support #antibody #drug development by enabling researchers to identify which antibodies have the potential to be most effective against current and future #Variant|s" Sai Reddy

ETH-Zürich (ETH Zurich) has put out a great summary of our DML technique and how it can help us develop more effective antibody therapies and vaccines against future variants of SARS-CoV-2. Read more about it here: ethz.ch/en/news-and-ev…

Here's the preprint by Ben Murrell and colleagues now posted, summarized in his thread biorxiv.org/content/10.110… "BA.2.75.2 was neutralised...five-fold less potently than BA.5... These data raise concerns that BA.2.75.2 may effectively evade humoral immunity in the population."

The Flotilla 13 elite unit was deployed to the area surrounding the Gaza security fence in a joint effort to regain control of the Sufa military post on October 7th. The soldiers rescued around 250 hostages alive. 60+ Hamas terrorists were neutralized and 26 were

My dad, who is a moderate Muslim, finally expressed his concern and asked me, 'Why are you supporting this genocide?' He mentioned that he's stopped looking at his phone because he can no longer bear to watch videos of Palestinian children being bombed by Israel. I replied, 'I

Excited to share my first last Author paper. Out now in Genome Biology We Buchholz Lab report two new methods. To evolve CRISPR-Cas systems (CaSLiDE) and to screen thousands of variants at once (DEQSeq) Thanks to the amazing team of co-authors! genomebiology.biomedcentral.com/articles/10.11…

Die Hamas ist eine Terrororganisation, die immer wieder ihre eliminatorische Absicht, Juden zu töten &den jüdischen Staat auszulöschen offen formuliert. Die Hamas benutzt ihre eigene Bevölkerung als Schutzschilde. Das ist der „Regierungsstil“ der Hamas. DAS wollen Irland, Spanien