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2-photon imaging goes freely-moving! We are releasing Mini2P, a 2.4g portable #twophoton 🔬 for fast multiplane calcium imaging of 1000s of neurons in behaving 🐭! Fully open-access. Now it is time to study natural behaviors! By Weijian Zong et al Kavli Neuroscience #KiloNeurons #ERCSyG

We're back after a two-year hiatus! Inviting applications for CAMP (Computational Approaches to Memory and Plasticity), an international computational neuroscience school, in-person National Centre for Biological Sciences, India. 23 Jul–7 Aug 2022. Details: camp.ncbs.res.in Please retweet!

The Best Scientists 🧵 I have heard a lot about the Best Scientists 🧑‍🔬 Maybe the best scientists... make impactful discoveries, publish in gilded journals, garner millions in funding, with lots of indirects. And prizes, all the prizes🏆 And everybody respects them. OR…

New paper! The PFC & hippocampus interact in many cognitive/emotional behaviors, but how the PFC exerts top-down control over hippocampus is a mystery. Ruchi Malik found long-range GABAergic projections from PFC to hippocampus performing this function (1/3): authors.elsevier.com/sd/article/S00…

These novel long-range projections GABAergic are actually DOUBLY DISINHIBITORY: by inhibiting disinhibitory VIP interneurons, they enhance feedforward inhibition in CA1. This also enhances the propagation of gamma oscillations across CA1 + PFC (2/3)

The net effect of all this is to enhance object-related spatial encoding by CA1 neurons and increase object exploration. IN SUMMARY: top down, doubly disinhibitory PFC inputs modulate CA1 network dynamics and information processing thereby promoting exploratory behavior (3/3)

Literature highlight of the week: Malik et al. identify a novel population of prefrontal long-range projecting interneurons that target VIP neurons in the hippocampus to increase spatial encoding and CA1-PFC gamma synchrony #top-down control sciencedirect.com/science/articl…

So well deserved! Congratulations John! 🎉

Excited to see our paper on Unsupervised discovery of brain states in Hide and Seek out today on Current Biology ! A massive exploration effort done by Bence Bagi Bence Bagi during his masters at Humboldt-Universität zu Berlin in the Brecht Lab. That continued through years of pandemic.

During navigation, landmarks are encoded not in single cells but in the collective hippocampal population dynamics. Excited to be part of this work with @anagelhus Sebastian O. Andersson Soledad Gonzalo Cogno May-Britt Moser Kavli Neuroscience #KiloNeurons #Neuropixels biorxiv.org/content/10.110…

great to see this out! expertly crafted by @DaveKoop highlighting work from Max Joffe Ruchi Malik candela and kirstie, hugo and hector who i dont have twitter handles for! PFC interneurons are cool! (esp when connected to hippocampus) jneurosci.org/content/42/45/…

New paper from the lab out today! Jeremy Biane, Max Ladow and team describe how neural population dynamics in dorsal and ventral CA1 evolve with associative learning and outcome expectation. Full text here: rdcu.be/c83t3

Finally getting this work out on Tsc1 in VIP+ interneurons. Great work from twitterless Jia Hu and Ruchi Malik in the Vikaas Sohal. mdpi.com/2073-4409/13/1…