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Excited to share two new papers, published today in nature! Check them out here: (1) Slide-tags, a new method to unite single-cell and spatial profiling: nature.com/articles/s4158…

A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of Fei Chen Lab & Evan Macosko. broad.io/slide-tags

Slide-tags adds spatial coordinates to single-cell sequencing measurements! Please explore the paper, published online today in nature! nature.com/articles/s4158…

As part of the NIH #BICCN effort, Broad researchers used their spatial transcriptomic technology to create a map of a mammalian brain, revealing remarkable diversity in understudied regions and uncovering clues to cellular function and roles in disease. broadinstitute.org/news/scientist…

It’s been a great year with the Chen lab!

We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11) biorxiv.org/content/10.110…

On the International Day of Women and Girls in Science, let’s help girls everywhere pursue careers in science, technology, engineering and math. Our world is better with their ideas and perspectives.

Kamala's mother immigrated from India to pursue a PhD & stayed to work as a cancer researcher Kamala's father immigrated from Jamaica to pursue a PhD & stayed to work as a professor Immigrant scientists contribute not only to science but to society at large -- for generations

With reconstruction, we can do Slide-seq/Slide-tags at higher throughput and larger scale. We applied it to a 1.2 cm P1 mouse section and UMAP learns the manifold over iterations.

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

New review & podcast alert! Our latest review in Annual Reviews delves into maternal B cell tolerance to the placenta & fetus. Check it out here: annualreviews.org/content/journa… (1/4)

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

Check out this awesome new spatial lineage tracing paper from Matt Jones Sun_Dawei Dian Yang! One of the coolest uses of Slide-tags yet. Was a pleasure to help out.

Pretty normal Thursday in the lab ... #placentasinspace #placentasinorbit #reproductiveimmunologyonthemoon Thank you MSKCC Integrated Genomics Operation for the fun party!

We’re excited to share our latest computational method, TissueMosaic, for comparative analysis of spatial transcriptomic datasets across conditions! (1/5) biorxiv.org/content/10.110…

We are excited to publish a spatially resolved single-cell multi-omic census of the placenta, contributing to the Human Cell Atlas project. The placenta plays an essential role in maintaining a healthy pregnancy, yet its function remains poorly understood. nature.com/articles/s4159…

Grateful to have been included in this incredible project, alongside such an amazing team!

1/ Thrilled to share an advancement in gene therapy from my PhD in Nature Communications! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to Feng Zhang & Mirco J. Friedrich! bit.ly/redicas9

Check out our new method of spatial transcriptomics with computational reconstruction on Nature Biotechnology. Make spatial transcriptomics easier and more accessible. idp.nature.com/authorize?resp…