Excited to share this discovery: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life, acquiring toxicity only when quite long (>150 CAGs). biorxiv.org/content/10.110…

Riaz Gillani, MD, and Ryan Collins in Eli Van Allen Dana-Farber report in Science Magazine that rare germline genetic abnormalities increase the risk of pediatric solid cancers, findings that could help improve treatments and screening. ➡️ bit.ly/3BQ04hK

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: Dana-Farber News Dana-Farber Division of Population Sciences Boston Children's Broad Institute Science Magazine science.org/doi/10.1126/sc…

Delighted to share that the peer-reviewed version of our study on germline structural variants in pediatric cancers was published yesterday in Science Magazine science.org/doi/epdf/10.11… Thanks as always to the patients, their families, and our funders for enabling this research!