Last experiment in Japan before going back to CA, #spatialtranscriptomics #NasuHakola disease!

Meet my 94-year-old grand uncle in rural Peru, with some mobility problems but cognitively sharp, making jokes, and telling me about all the other relatives I need to visit, especially my other tio-Abuelo, who turned 100 last year. Tempted to take some blood samples #healthyaging

Delighted to share our paper in StemCellReports on a novel 3D #iPSC-derived model of GRN- #FTD with a focus on astroglia toxicity. Fantastic collaboration with Ullian Lab HuangLab Kampmann Lab Synapticure Alector and others. #ALS #Organoids #TDP43 cell.com/stem-cell-repo…

Jackson Pollock or spatial profiling? A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain biorxiv.org/content/10.110… Preprint Allen Institute of whole mouse brain atlas, comprised of >11 million single cells profiled with scRNA seq & MERFISH 🤯

⭐️Cellular foundation for a new perspective of AD pathophysiology⭐️ 👉Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease biorxiv.org/content/10.110… Outstanding work from Naomi Habib - Habib Lab 💔 and Philip L. De Jager labs!👏👏

We are excited to release Seurat v5- with new methods for multimodal, spatially resolved, and massively scalable single-cell analysis. satijalab.org/seurat

When you leave but never really leave ;)Schizophrenia research 🎯 Excited to contribute to understanding this complex disorder. #JikeiUniversity #spatialtranscriptomics #Japanbrainbank

Scientific discussion and brainstorming session to push our ideas and improve our research. Good times with Julio Leon and Jordan Ramilowski.

Single-nucleotide variant calling in single-cell sequencing data with Monopogen | Nature Biotechnology nature.com/articles/s4158…

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in Cell today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful

Massive effort, honored to be part of it !

I’ve been awarded an Alzheimer's Association grant for my research that combines a multimodal approach to understanding the brain’s molecular pathological changes in aging and AD. Thanks to Carlo Condello, JayShin, Nakabeppu, and Kubo Sensei for their support and mentorship. #ALZFunded

Our new paper from the Frydman Lab published in Science Magazine identifies 22 TRiC mutations in patients with brain disorders of unknown origin. We characterized these disease-linked mutations in 3 model species and found them to be dominant mutations. science.org/doi/10.1126/sc…