Call for abstracts and pre-registrations are open for the XIXth Symposium on Chemistry of Nucleic Acids Components, June 8-13, 2025, Český Krumlov (Czech Republic). scnac.com

Our newest paper on enzymatic construction of reactive squaramate-linked RNA probes for covalent cross-linking with Lys-containing peptides and proteins (incl. viral RNA polymerases) published in Communications Chemistry doi.org/10.1038/s42004… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Our new paper (with P. Rezacova group) on the use of environment-sensitive fluorescent nucleotide in DNA probes for identification of effectors of TFs and studying conformational changes of protein-DNA complexes published in RSC Chemical Biology : doi.org/10.1039/D4CB00… IOCB Prague

Deadline for oral presentation abstracts for the XIXth Symposium on Chemistry of Nucleic Acid Components, Cesky Krumlov, June 8-13,2025 (scnac.com) is close (February 20, 2025) - if interested, please apply!

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA displaying 4 different cationic groups just published in @NAR_Open - see: doi.org/10.1093/nar/gk… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Our newest paper on enzymatic synthesis of hypermodified DNA bearing functional groups mimicking amino acid side chains in enzyme active sites just published in ChemEurJ: Chemistry - A European Journal . doi.org/10.1002/chem.2… IOCB Prague VŠCHT / UCT Prague Faculty of Science of Charles University Akademie věd ČR

Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has been published in @chembiochem : doi.org/10.1002/cbic.2… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Polymerase synthesis of base-modified DNA scaled-up to milligram quantities suitable for NMR structure studies. Check our newest work published in ChemistryEur doi.org/10.1002/ceur.2… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation - new paper in collaboration with C. Cardoso group published in Adv. Sci. : doi.org/10.1002/advs.2… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Our newest paper Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase-Modified Aptamers Demonstrated on Indole-Modified β-Conglutin Aptamer published in ChemBioChem : doi.org/10.1002/cbic.2… IOCB Prague Akademie věd ČR Faculty of Science of Charles University