STMiner: Gene-centric spatial transcriptomics for deciphering tumor tissues dlvr.it/THycbd

Online now! Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies dlvr.it/THyfcm

Huge congrats to the Singapore researchers whose groundbreaking study on alternative splicing and complex traits using #Chromium #singlecell was recently published in Orli Bahcall! Read more: go.nature.com/3WJbdZa Join our webinar on Feb 18: 10xgen.com/1JF

An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders promise of GLP-1RAs could materialize for several cognitive and mental health disorders potential GLP-1RAs in cognitive and mental disorders nature.com/articles/s4422…

After working so tirelessly to slash the country’s budget for sport, it’s absolutely amazing that this fella still has the guts to make a social media post celebrating the country’s baseball team qualifying for the World Baseball Classic. Shameless politician.

Protective ApoE variants support neuronal function by extracting peroxidated lipids biorxiv.org/content/10.110…

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease | Nature Medicine nature.com/articles/s4159…

Multi-ancestry meta-analyses of GWAS data from European and non-European backgrounds report 16 new AD-associated loci. ow.ly/OlOj50ViyR7

Aging is an energetic process The Brain-body Energy Conservation (BEC) model of aging predicts that the brain can slow down energetically expensive functions to prolong lifespan nature.com/articles/s4358… A new paper in mice shows that the brain can slow down biological aging by

spVelo: RNA velocity inference for multi-batch spatial transcriptomics data biorxiv.org/content/10.110…

54K WGS! Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels nature.com/articles/s4158…

Is this Magic?🧙 Scalable, imaging-free #SpatialTranscriptomics through molecular diffusion-based computational array reconstruction Slide-seq Slide-tags "the bead barcode diffusion process generates information in a high-dimensional space in which physically closer bead

Edible mRNA vaccine in lettuce chloroplasts bit.ly/42xbnou

For readers interested in drug development for neurodegenerative diseases, this review in the April issue discusses mitophagy enhancement with compounds such as USP30 inhibitors and PINK1 activators as a therapeutic strategy tinyurl.com/bddchuez rdcu.be/ehQWc

🧪 Exciting opportunity! Join the Royer/Jacobo labs @CZBiohub SF! We're seeking a Spatial Molecular Cartography Scientist to push the limits of 3D transcriptomics in zebrafish. Expertise in HCR/FISH techniques wanted! Help us map gene expression at unprecedented detail.

Most genetic variants are assumed to influence disease risk by effects on gene expression. While most variants can affect the expression of multiple genes, existing methods map a single gene at a time. Clustering the expression of neighboring genes can improve eQTL discovery👇

#SpatialTranscriptomics #Atherosclerosis Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions scRNAseq GeoMx Bruker Spatial Biology smFISH 🔥#SmoothMuscleCell Fibroblast T #Senolytic ABT-737 ⏫plaque collagen fibers, ⏬necrotic core, ⏬serum

While UK Biobank enabled access to population-based proteomics at scale, most omics studies in disease-focused cohorts still suffer from small sample sizes. The Global Neurodegeneration Proteomics Consortium brought together 35,000 serum, plasma, and CSF samples from

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging Science Immunology Manuel M. Gómez de las Heras Mittelbrunn Lab science.org/doi/10.1126/sc…

Can antivirals against herpes treat early-stage Alzheimer's? At #AAIC2025, researchers presented data from a clinical trial showing no effect. My latest for Being Patient 1/6