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The human mitochondrial mRNA structurome reveals mechanisms of gene expression Science Magazine Antonio Barrientos Rouskin Lab Flavia Fontanesi science.org/doi/10.1126/sc…

1) Just out nature today! We show that human TMEFF1 is a restriction factor for #Herpes simplex virus 1(HSV1) in the brain, by limiting NECTIN1—HSV1-gD mediated HSV1 entry into cortical neurons. TMEFF1 defect can underlie HSV1 #encephalitis. nature.com/articles/s4158…

Extremely proud of our Systems_Immunology_WIS member lab Ziv Shulman Lab for their fascinating study nature decoding the local nasal immune response and related niches in response to nasal vaccination- way to go guys, this is immunology at its best!! nature.com/articles/s4158…

Our latest paper led by graduate student Mike Ohman is out today in PNAS! 🎉Mike showed the HCMV Pentamer glycoprotein complex inhibits viral immediate early gene expression. Congrats to Mike & co-authors Emily & Chris! pnas.org/doi/10.1073/pn…

Part 1 of our venture into the world of alternative translation-linked proteoforms! (Now Dr) Paul Lee, Yu Sun, along w/Alexa Soares and others in Marina Picciotto lab found that alternative TIS pairs change the localization and functions of synaptic organizers! authors.elsevier.com/a/1jpc73vVUPRm…

Our paper out today @nature: phages reconstitute NAD+ to counter bacterial immunity Phaged invented a new biochemical pathway for NAD+ synthesis - including previously unknown enzymatic reactions - to evade bacterial defenses Congrats Ilya Osterman! nature.com/articles/s4158…

New 📜 in NatureStructMolBiol - "Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity", by Sveta in my lab, Omer Ziv Eric Miska and Lau and Greg Kudla lab. Been a while since preprint, so a 🧵 nature.com/articles/s4159…

We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA. biorxiv.org/content/10.110…

We are excited to share our latest research, a joint effort between the Hennig group at EMBL Heidelberg and the Castello Lab at MRC-Uni of Glasgow Centre for Virus Research . We’ve uncovered the key residues for the RNA binding of TRIM25, which plays a key role in its antiviral activity. 🔗 nature.com/articles/s4146…

I am excited to co-organize Keystone Symposia #RNA Mediated Regulation of #Immunity: Mechanisms, Disease and Therapeutics, this January. Its a great opportunity for the RNA and immunology communities to meet and discuss recent advances. Deadlines are approaching, please join us!

Now accepting applications for the Max Planck-Weizmann Joint Postdoctoral Program: • Full four-year fellowship • Advanced research facilities • Access to leading experts • Enhance career perspectives • Comprehensive family support For more info and to apply >>

Our latest research ‼️🚨🚨 ‘Zika viruses 🦠 encode 5’ upstream open reading frames affecting infection of human brain cells 🧠’ What does it mean? 👇🏾👇🏾👇🏾 nature.com/articles/s4146…

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & Ilya Osterman

Tomorrow (Oct 29th) is the deadline for #KSRNAImmune25 scholarship and short talk considerations. Please submit your abstract if you have not already done so.

Our new preprint on the establishment of cytomegalovirus latency, a 🧵

New lab 📰 in Nucleic Acids Res, the 2nd paper of star postdoc Sveta Farberov. A tour-de-force into how we can use MPRAs to understand binding-function landscape for RBPs. We address the following Qs: academic.oup.com/nar/advance-ar…

Last chance for scholarship applications for RNA mediated regulation of immunity KS.

Excited to announce the 2025 Nucleic Acid Tx meeting - on 5/2/25 Weizmann Institute (a re-incarnation of an RNA Tx meeting in 2023). Great speakers from academia/industry. Co-org with Stern-Ginossar lab Schraga Schwartz 𝄃𝄃𝄂𝄂𝄀𝄁𝄃𝄂𝄂𝄃-⚪ Yaniv Erlich יניב ארליך Yogev Debbi. Abstract submission/free reg. link below!

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…