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📖 A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana 🏠 bioRxiv Plant Bio Steve Jacobsen Basudev Ghoshal biorxiv.org/content/10.110…

We’re excited to share that we’ve raised $208 million in our latest fundraise which will help accelerate the advancements of our science platform and product development for corn and soybeans.

We broke ground on our SEEDesign greenhouse expansion! Expanding our capacity to develop step-change products with predictive design & multiplex gene editing. Thanks @GovHolcomb, Indiana Economic Development Corp. Purdue Ag Dean, state/local officials who joined us as we expand our footprint in IN.

So happy to share my first paper, published today in Science! 😊 science.sciencemag.org/content/early/… How does DNA methylation repress genes and transposons? What acts downstream of the methyl-mark? Such a fundamental question. Yet, in plants this was pretty much unknown 👇👇 Steve Jacobsen

We are looking for a postdoc to join a team creating CRISPR-based tools for controlling gene expression by targeting different types of DNA methylation related and non DNA methylation related epigenetic modifications.

Inari Agriculture has a bunch of open positions in Boston, Ghent and Indiana. inari.com/careers

Very honoured to have been elected an EMBO member - thank you very much to all who supported my election & group members & colleagues who helped me achieve this!

Very excited that our efforts to identify the elusive CMD2 gene for Cassava Mosaic Disease resistance are finally published Nature Communications. Very proud to be part of this project – stuff like this is why I got into plant science! nature.com/articles/s4146…

My second paper is available in biorxiv! We discovered that the transcriptional derepression that we observed in mbd5/6 and silenzio mutant plants last year (science.org/doi/10.1126/sc…) was actually happening only in pollen! Why?👇 biorxiv.org/content/10.110… Steve Jacobsen

Integrative Epigenetics in Plants #CSHAsia Abstract submission deadline is Oct 21. Keynotes by Profs. Steve Jacobsen Steve Jacobsen and Tetsuji Kakutani. Come and see amazing speakers at Awaji, Japan in December! Japan resumes VISA-FREE entry for travelers from 68-countries.

Check out the latest efforts led by Zheng Li and Steve Jacobsen, on applying CasΦ towards editing plant genomes!

Congrats to Basem Al-Shayeb, Ph.D. 🧬 Evan Groover Dylan Smock Amy R Eggers @patrick_pausch Brady Cress Brian Staskawicz Dave Savage Steve Jacobsen @doudna_lab et al. on their work discovering the diversity of #CRISPR systems in phages! Thanks for using #crispresso2! doi.org/10.1016/j.cell…

Cool epigenome editing screen from Steve Jacobsen. They found the first protein I ever published on: JMJ14 (K4 demethylase). JMJ14 leads to silencing of the target, but no change in DNAme (or K27me3). We saw in the jmj14 mutant there was a DNAme defect 🤔 nature.com/articles/s4147…

Jasmine Amerasekera U.S. National Science Foundation Scribe Therapeutics Steve Jacobsen Congrats Jasmine!!!

The mechanism of MBD6 mediated silencing of genes and transposons. Beautiful story😍 Congratulations Brandon Boone , Steve Jacobsen and colleagues 🎉🎉🎉

Excited to share a new paper from the CRISPR team in the Jacobsen, Doudna, and Banfield labs on viral delivery of TnpB and wRNA for transgene free germline editing in plants. biorxiv.org/content/10.110…

Why is it that gene promoters are so good at avoiding DNA methylation? Work from Ming Wang, Yan He et al., shows that H3K4me3, enriched at promoters, acts as an anti-DNA methylation mark by recruiting DNA demethylase enzymes! Nice work guys! rdcu.be/d9rPo

Excited to share work from Zhongshou Wu in our lab showing that GDE1 and REM transcription factors help shape DNA methylation patterning. Together with work from Julie Law’s lab also just out, this shows an important way that genetics directs epigenetics. biorxiv.org/content/10.110…

Amazing new 📜 from Trevor Weiss and Steve Jacobsen showing the creation of transgene-free, genome-edited plants which pass those edits to the next generation using viruses and TnpBs🤯🤯 nature.com/articles/s4147…

Our paper is just out nature.com/articles/s4147… from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x.  Looking for postdocs to join the team for the next phase of this work!