Join us in the fight against motor neuron disease as a clinical trials research fellow. The deadline for applications is Monday 9th August. King's MND Centre Neurology Trainees jobs.kcl.ac.uk/gb/en/job/0284…

In #ALS, we show that motor units recruited at low force levels adopt a faster phenotype as disease progresses. This compensation is likely to be beneficial at first but may become detrimental over time. King's MND Centre Medical Research Council MND Research Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

What role do first-recruited #motorunits have on the progression of Amyotrophic lateral sclerosis? #ALS Interesting new study from SPiQE King's MND Centre 👉 buff.ly/3k6dgmS

A valued editorial in Brain outlining the challenges faced by clinician scientists. We remain resolute to the cause, although a bit of bureaucratic streamlining would be very welcome. doi.org/10.1093/brain/…

In this article, we propose a noninvasive method for estimating motor unit number without the need for electrical stimulation. This would be a valuable addition to the ALS biomarker field. King's MND Centre frontiersin.org/article/10.338…

In this review, we highlight the breadth of neurophysiological outcome measures used in #ALS interventional trials. We recommend the need for improved standardisation of techniques as we move forward. King's MND Centre sciencedirect.com/science/articl…

James Bashford in our research group is running this year’s #LondonMarathon in memory of a close friend. He is raising money for Cardiac Risk in the Young Cardiac Risk In The Young Unoffical and would very much appreciate your support. Training in this heat is no easy feat! justgiving.com/fundraising/ja…

In this article, we show that the duration of surface EMG recording needed to obtain useful fasciculation measurements can be halved to 15 minutes without compromising on the outputs. This will aid home-based assessment. King's MND Centre doi.org/10.1002/mus.27…

We are excited to reveal we are now ‘device-ready’ for our remote home assessment of ALS patients (RHAALS) study. We will monitor motion patterns, sleep behaviour and vital signs for 12 months to better understand disease progression. UK Dementia Research Institute King's MND Centre #ALS

In our serial transcranial magnetic stimulation study, we have so far recruited 11 #ALS patients, 4 neurological controls and 9 healthy participants. We hope to quantify ALS motor dysfunction in a novel way. King's MND Centre Medical Research Council Autifony Therapeutics kcl.ac.uk/spiqe/our-rese…

Cheers to the lovely folk at King's College London SPiQE for a positively engaging and empathetic afternoon doing MND research :-)

We recently showed that there is a prolonged lag between the electrical and mechanical peaks of fasciculations in #ALS This quantitative approach requires further validation as a disease or prodromal biomarker. King's MND Centre #alsmndsymp sciencedirect.com/science/articl…

I was recently reminded of the fasciculation vs fasciculations debate. In this article, I argued there is need for both, as in ‘Fasciculation consists of numerous fasciculations’. This is necessary for quantification. Thoughts? pn.bmj.com/content/20/3/2…

Motor hyperexcitability phenomena lie on a spectrum, ranging from fasciculation potentials (solitary) to myokymic discharges (pairs/triplets <150Hz) to neuromyotonic discharges (multiplets >150Hz). Find out more here: pubmed.ncbi.nlm.nih.gov/34130251/ #ALS King's MND Centre #OpenAccess

In 2020, we summarised motor unit behaviour in #ALS As affected motor units become hyperexcitable and then die, surviving motor units branch and maintain muscle strength. But, this compensation is eventually overwhelmed. ncbi.nlm.nih.gov/pmc/articles/P… King's MND Centre MND Association #mnd

📣 Research opportunity 📣 Judith Bilgorai and SPiQE are developing a new way to measure muscle activity and #MND progression. They are looking for people with MND and their family or carers to help test this new method. Find out more ⬇ mndassociation.org/research/get-i…

📣 Research opportunity 📣 Judith Bilgorai and SPiQE are developing a new way to measure muscle activity and #MND progression. They are looking for people with MND and their family or carers to help test this new method. Take part ⬇ mndassociation.org/research/get-i…

📣 Research opportunity 📣 Judith Bilgorai and SPiQE are developing a new way to measure muscle activity and #MND progression. They are looking for people with MND and their families/carers to help test the new method. More info ⬇ mndassociation.org/research/get-i…