Sometimes single-minded dedication to a problem is the path to great science. I’ve never met someone more focused on a problem than David Baker. Among the postdocs at UCSF in the early ‘90s, none of us would have been surprised to learn there was a Nobel Prize in David’s future.

I'd also like to add that, in addition to being a brilliant scientist, David is an incredibly supportive mentor and genuinely amazing human being - I am incredibly grateful for his help, guidance and friendship!

We recently spent a day in the lab with 2024 The Nobel Prize winner and HHMI Investigator David Baker, where he discussed his groundbreaking work, the importance of basic science, and his passion for mentorship #NobelPrize

♥️♥️♥️

Absolutely nuts!!! History made! Congrats to your whole awesome team!

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4

Hey folks, I know most deadlines are fast approaching, but I am applying for assistant professor positions this cycle, and I would appreciate recommendations for open positions! My research plan is focused on MGEs, genome engineering, and applying AI to biological discovery.

Great faculty position in VIDD @Fredhutch open-strong support from the Bezos family included! Please apply and/or RT!

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

Please consider working with us! We have a wonderful growing team and exciting roadmap ahead.

New work by Mia Yang's lab reports evidence of prevalent aneuploidies in human trophoblast stem cells and suggests that chromosomal instability may be a normal feature of placental development. biorxiv.org/content/10.110…

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RT!!! 1/3 experiment.com/programs/plants

E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵

Grateful for the support of the Sontag Foundation, we’re excited to do this important work!

We need more programs like this one (FutureHouse) to bring new ideas into the biological sciences. As mentioned in the fellowship link, our lab is excited to co-advise fellows who want to solve the world’s biggest problems with cutting edge tools. DM me if you want to talk

Since we announced the FutureHouse AI for Science Fellowship, we've had a bunch more amazing professors sign on as potential co-advisors: Sergey Ovchinnikov (MIT) Ellen Zhong (Princeton University) Patrick Hsu (UC Berkeley/Arc Institute) Pratyush Tiwary (University of Maryland)

Our annual DSA scientific retreat is just around the corner! We will be celebrating our 2024 DSA winners: ZZ Zhao Zhang, Hua Wang, Sanjay Srivatsan, and Cathryn Cadwell. If you would like to become a DSA awardee, the application portal is now open! bit.ly/3uJMmJo

New preprint! We carried out the largest complementation and inhibition study for diverse homologs in a single protein family (DHFR) to date. Highlights thread follows... 1/n 🧵

Hiring alert! Sanjay Srivatsan Fred Hutch Cancer Center and I HHMI | Janelia are looking for a joint postdoc to combine single-cell omics and ex utero embryogenesis. Please retweet! If you are interested, DM us or send an email to [email protected] ; [email protected]

Procrastinators unite! 4 hours left for Flux applications!