Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons biorxiv.org/cgi/content/sh… #bioRxiv

Check out our new review article about lysosomal proteomics in clinical samples which was published today in Expert Reviews of Proteomics Taylor & Francis Research Insights ! Congratulations to Dhriti, Yannic, and Jiaran for their first paper 🥳 tandfonline.com/doi/full/10.10…

Congratulations to Sacha on winning the popular poster prize in this years graduate poster symposium 🎉 ⁦Department of Biochemistry at Oxford University⁩ ⁦Kavli Institute for Nanoscience Discovery, Oxford⁩ ⁦Oxford BBSRC DTP⁩

Where do new senses come from? In paired studies, we explore the structural basis of sensory receptor evolution in octopus and squid. @CoreyAHallard Wendy Valencia @RyanHibbs10 nature - nature.com/articles/s4158… - nature.com/articles/s4158…

pnas.org/doi/10.1073/pn… Next generation of membrane protein single particle cryo-EM is here. Amazing works from my colleagues Chen Zhao and Xiao Tao. High resolution structure of Slo1 in near native conditions - no detergent at all!

Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology | Science Advances science.org/doi/10.1126/sc…

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べたら閾値が哺乳類よりも低く、アンキリンリピートが温度の閾値の差異に関わるかもというお話 nature.com/articles/s4146…

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate スフィンゴシン輸送体の6状態の構造。MBPを使うことで抗体を使わずに構造が決まってるらしい cell.com/cell/fulltext/…

Our group has been awarded a Silver LEAF - recognising everyone's efforts in setting up sustainability initiatives, reducing waste and increasing efficiency in the lab and department! Thanks to Jo for organising and keeping it all on track. Department of Biochemistry at Oxford University Kavli Institute for Nanoscience Discovery, Oxford

new release5 8P6A: cryo-EM structure of human SLC15A4 in outward-open state Newstead lab.

Let’s work together ! #ChooseFrance 🇫🇷

Thinking of simulating anion protein interactions? David Seiferth's work is now out in PCCP: Limitations of Non-Polarizable Force Fields in Describing Anion Binding Poses in Non-Polar Synthetic Hosts -pubs.rsc.org/en/content/art… Congrats David! with Stephen J. Tucker as well.

I'm very excited to share our latest publication on Nature Communications describing how the #BattenDisease protein #CLN3 is critical for #lysosome biogenesis and reformation, uncovering a novel disease mechanism. Texas Children's Tigem Telethon rdcu.be/dfV90

And here is the finalised paper nature.com/articles/s4159… again, super work from Kato , Dr Jo Parker & Dr Gabriel Kuteyi - go team!

Congratulations to Franco Viscarra on his work that reveals what dictates positive allosteric modulation of alpha7 nicotinic receptors - now out in ACS Chemical Neuroscience. Lovely collaboration with Lopez, Bermudez and Bouzat groups and colleagues! pubs.acs.org/doi/10.1021/ac…

Geneticist J. Craig Venter talks sequencing the ocean, setting up a health-screening company after checking his own genes — and why he has no plans to stop. go.nature.com/3LrCZ6M

In order to replicate, malaria parasites must get inside our red blood cells. How do they do it, and how do antibodies which block red blood cell invasion work? Check out our latest discoveries eLife - the journal in a study led by Abhishek elifesciences.org/articles/83681

OTOP1 is not just a sour receptor, it also mediates ammonium chloride taste. Never tasted NH4Cl? It’s in salty licorice – beloved in Scandinavian countries. Our paper in Nature Communications goes from channel biophysics to behavior. rdcu.be/dnPGI.

Looking forward to the NY Area CryoEM meeting Thursday! Some great talks lined up from Puja Majumder, sacha salphati, Gabriele Cerutti, @SamSustek, Lars Dingeldein, Jianping Li, Ziao Fu and Yan Li, plus many exciting posters! 🙏 for support from sponsors ⬇️, & see you Thurs! ❄️🔬

Out just now in eLife - the journal: MD simulations combined with transport assays to study energy and substrate coupling in the mechanism of the mammalian peptide transporter PepT2. Work with Jo Parker, Simon Newstead and Phil Biggin 🇪🇺 . doi.org/10.7554/eLife.…