Insights into sorption and desorption mechanisms of PFOA’s cationic and zwitterionic precursor compounds ow.ly/Btly50wItIn

To all my macrophage friends: check out this awesome work by @ashishkulkarny and co-workers. Dual‐inhibitor‐loaded nanoparticles target M2 macrophages and simultaneously inhibit CSF1R and SHP2 pathways to repolarize TAMs.

Happy #PhytochemicalFriday! Today: allicin, a (zwitterionic!) compound from garlic. Normal garlic cells contain alliin (an amino acid-like compound), but crushing garlic exposes alliin to an enzyme that converts it into allicin - the major contributor to the aroma of fresh garlic

.Monica Guzman & colleagues analyzed PTPN11-mutated #AML samples for sensitivity to epichaperome inhibition, a new cancer-targeting strategy. Findings were presented at #ASH19 by Weill Cornell Medicine NewYork-Presbyterian Hem/Onc Fellow Dr. Justin Kaner (@WxMD529). bit.ly/2qdEP4C

Clinically, this suggests that this resistance can be potentially overcome by targeting the specific RTK resistance mechanism — or perhaps by targeting nodes of convergence like MEK or ERK or SHP2, which would allow treatment of more disparate resistance mechs w fewer drugs

Many thanks to our many collaborators and colleagues, and to our funders for supporting this work

"Individualized medicine, for us, is really understanding as much about each individual patient as we possibly can,” says @akeithstewart. to.pbs.org/308UBv7 via PBS News PBS Miles O'Brien

Following guidance from the Department of State and CDC and #UNC’s prohibition of travel outside of North Carolina, all summer 2020 study abroad and international education programs are canceled. This includes undergraduate, graduate and professional programs unc.live/3cWFV8x

Due to the University's updated COVID-19 operational plan, many upcoming events have been canceled, postponed or altered. Please see global.unc.edu/events for status updates on event changes.

There is no treatment for 90% of rare diseases. Personalised medicines can target such illnesses econ.st/3cZVmN6

This past week has challenged each of us in unique ways, but we can all share the common experience of confronting unexpected challenges. We also share the truth that we can’t do this alone. Don’t be afraid to ask for help, and don’t be afraid to offer help to others.

Dear elected officials for NC, we need some help. Please help us find #3Dprinters in the Charlotte area. We need #faceshields #masks #PPE for our healthcare teams caring for pts. #COVID19 We need printers, supplies, & some humans to help. Thx 🇺🇸

Watch RAS wiggle! Here is our latest structure showing dynamics of a KRAS mutant found in RASopathies - KRAS P34R (mutation in red). Interesting connection with heterotrimeric G proteins. onlinelibrary.wiley.com/doi/10.1002/bd….

Doctors, nurses & ALL healthcare providers need adequate Personal Protective Equipment so they can treat patients without spreading COVID & also safely protect themselves. Everyone can help us! Here is how: CC: Darilyn Moyer ACP Please share w/ everyone you can🙏

ICYMI - informed and thoughtful perspectives on Preparing for the Next Pandemic from an extraordinary leader, Dr. Dr. Sue Desmond-Hellmann, who has led important institutions across sectors including Gates Foundation and UC San Francisco. The Wall Street Journal

#DYK what makes a translational scientist? Translational scientists break down barriers & facilitate connections with researchers to speed up the process of scientific discovery. Learn about the other characteristics they share in our video: bit.ly/39xvtS7

#Nevada Rep. Steven Horsford joins #TheLauraCoatesShow to discuss the "America's Workforce Act" and the companion bill "The National Apprenticeship Act" and the disparate economic impact of the pandemic on women on @SXMPOTUS SiriusXM! Join the conversation!

“My CV makes it look easy, but it hasn’t always been. For every paper or grant I have submitted, 80-90 % of them have been rejected, which is why I tell my students they have to love the pursuit of the question.” -⁦CDC Director⁩ ⁦Rochelle Walensky, MD, MPH⁩ vogue.com/article/dr-roc…