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Our new paper is online! We have a nice tool to assess glycolysis in cells. Fantastic work of Isra and collaboration with Messens Lab! Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor: iScience cell.com/iscience/fullt…

Leveraging the TSE Systems PhenoMaster NG platform, Dr. Gurzov’s team Signal Transduction & Metabolism Laboratory explored the regulatory pathways of RPTPs. The research demonstrated that increased expression of hepatic PTPRK elevates glycolysis and activates de novo lipogenesis. Read: nature.com/articles/s4146…

Our F.R.S.-FNRS Aspirant PhD student won the Best Poster Award at the meeting of the Belgian Society for Stem Cell Research (BeSSCR). Look how happy she is! 🙂 Well done Valerie Vandenbempt! #BeSSCR #StemCells

Comment l'obésité favorise le développement du cancer du foie ? Découverte du Laboratoire Transduction du signal et métabolisme Université libre de Bruxelles, dirigé par Esteban Gurzov, Maître de recherches FNRS @televie WEL Research Institute 🔗urls.fr/aEcu54 L'article : urls.fr/XJJOlN

Happy to have joined the Convening Emerging Leaders to Find T1D Solutions meeting in Charlottesville. Thank you to the Manning family foundation and breakthrough T1D for the amazing event and for supporting the next generation of scientists! Together we will make it happen!

It was very exciting to participate in the FASEB Protein Phosphatases conference at Palm Springs, CA #PROSRC

We are very happy with the award! 😊

Despite the diverse nature of obesity, there is compelling evidence that suggests brain circuits play an important role. A Review in The Lancet Diabetes & Endocrinology provides an overview of hypothalamic obesity, with a focus on new avenues for diagnosis & treatment: hubs.li/Q030V3J00

A huge shoutout to the amazing PhD student Sema Elif Eski who lead the project, helped by Macarena Pozo-Morales, our amazing team, collaborators Jiarui Mi Olov Andersson Signal Transduction & Metabolism Laboratory , and funders F.R.S.-FNRS who made this work possible. 🙌 (10/12)

What if single-cell analysis of 1,000 samples wasn’t just imaginable—but affordable? Imagine analyzing 1,000 samples at the single-cell level, each containing ~25,000 cells or nuclei. That’s ~25 million cells in one experiment!. Until now, the costs of such an experiment were

We provide herein an overview of #hypothalamic #obesity, departing from the hypothalamic pathways governing bodyweight and focusing on putative mechanisms and new avenues for diagnosis and treatment of this condition thelancet.com/journals/landi… #hyperphagia

Our latest Review article is online! 😊 Gilglioni David Hay Therapeutic potential of stem cell‐derived somatic cells to treat metabolic dysfunction‐associated steatotic liver disease and diabetes - Gilglioni - Obesity Reviews - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…

Mouse and human data suggests that a potent SCFA immunomodulator promotes multiple beneficial pathways and supports targeting the microbiota as an approach against #T1D nature.com/articles/s4146… Nature Communications

We have generated human TXNIP knockout stem cells for metabolic studies. This initial work can facilitate future efforts in TXNIP-targeted therapies and drug screening, offering valuable controls to test specificity and efficacy. stemcellres.biomedcentral.com/articles/10.11…

We just posted our new preprint, spearheaded by Garnik Hovhannisyan with Signal Transduction & Metabolism Laboratory ! biorxiv.org/content/10.110… #zebrafish #liverregeneration #DevBio #LineageTracing biorxiv.org/content/10.110…