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.Konstantopoulos Lab and colleagues show that SWELL1 and NHE1 regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis Sean Sun go.nature.com/3DhlEtu

Many thanks to nature for their research briefing highlighting our article Cancer cells move and spread faster in thicker extracellular fluids nature.com/articles/d4158…

Congrats to Kaustav and the Konstantopoulos lab Konstantopoulos Lab! Exciting new publication in Nature: nature.com/articles/d4158…. Glad to be a part of it!

Extracellular viscosity liked to cancer spread. An international team in which the Molecular Physiology Lab at the UPF participates has published the results of this research in nature journal. DOI: doi.org/10.1038/s41586….

We Sean Sun will host a new Subgroup session at ASCB 2022 #CellBio2022 American Society for Cell Biology: "Water Dynamics in Cells and Tissues". 11 amazing talks on ion, pressure, cell size, motility, and more related to water flux! See you on Dec 3, Sat, 9:30AM-12, RM201!!

1/ Celeste Nelson Tissue Morphodynamics Group: "Fluid Pressure Promotes Morphogenesis of the Lung".

2/ Alex Kiepas Konstantopoulos Lab: "Counterintuitive Effect of Extracellular Fluid Viscosity on Enhancing Cell Migration and Cancer Dissemination".

3/ Bin Sheng Wong Bin Sheng Wong Rong Li Lab: "Chronic Hypo-Osmotic Stress Induces p53-Dependent Cell Cycle Arrest To Guard Against Genome Instability".

4/ Yizeng Li: "Polarized NHE1 and SWELL1 Regulate Confined Water-Driven Cell Migration: Experimental Discoveries and Theoretical Interpretations".

5/ Gawoon Shim Gawoon Shim, Daniel Cohen Daniel J. Cohen (CohenLab at Princeton): "Bioelectric regulation of tissue hydrostatic pressure in tissue spheres and organoids".

6/ Mugdha Sathe Mugdha Sathe at Theriot lab: "Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer".

7/ Chloe Roffay Chloé Roffay Roux Lab: "Uncoupling the mechanics of membrane tension and cell volume".

8/ Alice Williart @PielMatthieu lab: "Deforming safely: nuclear envelope folds define two regimes of nuclear volume, pressure and tension".

9/ Myself Qin Ni Sean Sun: "Mechanosensitive cell volume regulation via actomyosin and ion transport".

10/ Ryan Petrie @Dr_Lobopodia: "The Ras-MAPK pathway regulates intracellular hydraulic pressure and the mode of 3D cell motility".

11/ Alex Mogilner: "Mechanics of cohesive leader-trailer cell pair migration".

No, our Universe isn’t made of pure mathematics bigthink.com/starts-with-a-…

Congrats on the latest work by the Mao Lab and the Sun Lab team: nature.com/articles/s4428…! What started as theoretical prediction in cell.com/biophysj/fullt…, has yielded many experimental fruits.

Wanna save $$$ while doing cell transfections. Transfection efficiency extremely low? Use this nature.com/articles/s4428…

Congrats to Qin and the team on publishing our latest work: cell.com/cell-reports/f…. The paper shows how NHE works with F-actin and other cell components to drive cell swelling and cell shape change.