📰 Our subanalysis of AFFIRM reveals (JCF Intersections): ! About half of AF patients had (undiagnosed) HFpEF. ! Class IC/sotalol linked to higher mortality in HFpEF. 🚨 Findings that call for caution. Many thanks to W. H. Wilson Tang, MD, Pieter Martens, Wilfried Mullens, Philippe B. Bertrand

What a thrill also to celebrate Sebastiaan Dhont - incredibly talented trainee, PhD candidate, and scientist who is the VERY FIRST lead author published in JCF Intersections

🔎We studied 2,452 patients across centers to assess mPAP/CO slope during CPETecho: ✔️ >3.5 mmHg/L/min = 3–4× ↑ risk of death/HF hospitalization ✔️ Adds value beyond HFpEF scores ✔️ Consistently reproducible “To assess exertional breathlessness, exert the breathless.”

👀 Great to see #CPETecho included in the new #VHD guidelines #ESC2025 for aortic stenosis! ➡️ Exercise testing is now highlighted not only for symptom unmasking, but also for risk stratification and uncovering hemodynamic intolerance.

🗞️🚴‍♂️ Atrial functional mitral regurgitation (AFMR) & exercise-induced changes in heart failure with preserved ejection fraction Just out in JACC Imaging: jacc.org/doi/10.1016/j.… Short thread 🧵

👀 Dynamics of AFMR during #ExerciseEchocardiography #CPETecho in JACC Journals ✨ TEAM ✨ Sebastiaan Dhont Wouter L’Hoyes Sara Moura Ferreira Philippe B. Bertrand 👇