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Our latest work is now out in bioRxiv: "An inter-organelle contact between endosomal GLP-1R, ER VAP-B, and the mitochondrial AKAP SPHKAP triggers PKA-dependent MIC19 phosphorylation and β-cell mitochondrial remodelling" biorxiv.org/content/10.110…

PhD position available in my group: Structure-based drug design with focus on machine learning. Apply here: jobb.uu.se/details/?posit…

THE FLORIDA PANTHERS ARE THE 2023-24 #STANLEYCUP CHAMPIONS! 😺

Excited to share our latest paper, where we describe ITSN1 as a novel risk gene for Parkinson's disease! We found that rare loss-of-function variants are associated with a 10-fold increased odds of PD. As far as we know, this is the largest effect size reported for sporadic PD

Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins | Science Advances science.org/doi/10.1126/sc…

Can AlphaFold be useful in drug discovery? Hell yes! In our paper, structure-based virtual screens using AlphaFold models identify potent GPCR ligands with antipsychotic effects in vivo (science.org/doi/10.1126/sc…). KAW @UU_University Karolinska Institutet SciLifeLab

A new study in Science Advances, conducted on mice, show that #AI with high precision can contribute to more effective future treatments for conditions such as #psychosis. news.ki.se/ai-accelerates…

Achieving optical transparency in live animals with absorbing molecules science.org/doi/10.1126/sc…

Researchers reveal how a cancer stem cell marker promotes the invasiveness and metastasis of gastric cancer, a new Review explores the role of aberrant GPCR signaling pathways in rare forms of melanoma, and more this week in #ScienceSignaling. scim.ag/8lu

I am pleased to share our publication on the crucial role of Nurr1 in modulating the response to hallucinogens in the claustrum. A huge thank you to Thomas Perlmann, Stefania Giacomello, Marie Carlén and Boehringer Ingelheim #Claustrum #Nurr1 #Hallucinations nature.com/articles/s4146…

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

New insights into Alzheimer’s Disease 🧠🔍 In a study with UW Medicine and KP WA Research, researchers have identified some of the first neurons lost in the progression of Alzheimer’s Disease and potential future pathways to #EndAlz. 🧵 #studyBRAIN

Looking forward to this! Karolinska Institutet

Cool and important paper! nature.com/articles/s4146…

Looking for a postdoc (pharmacology) to join one of our exciting projects focused on G protein-coupled receptors. Experience in signalling assays is required. You will be working in an interdisciplinary team to understand the activation mechanism and design ligands. Contact me!

Congrats to the team: especially Hye Jin Kang and Brian Krumm from Bryan Roth and Adrien and Matan from Greg Scherrer's lab!! A ton of work! Structure-guided design of a peripherally restricted chemogenetic system: Cell cell.com/cell/fulltext/…

Excited to share our new study! We identify Anxa1 neurons as particularly vulnerable in Parkinson’s disease. We also show their crucial role in prodromal-phase bradykinesia and procedural motor learning.

Excited to share our latest manuscript from my previous lab, exploring the neuroanatomical and molecular mechanisms underlying atypical antipsychotics! #p11 , #antipsychotics , #serotonin ,#fUS . nature.com/articles/s4138…

What is the best way to find drugs among sextillions of compounds? In our just-published Nature Communications paper, we show that fragment-based virtual screening is an efficient approach to design enzyme inhibitors. Check it out! nature.com/articles/s4146…