New #AlphaFold materials now live! Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase capacity and enable more researchers to use the #AlphaFold system and database. View the free course materials: ebi.ac.uk/training/mater… EMBL-EBI

In Science Translational Medicine, scientists harness silica nanoparticles to remodel the spleen into a hospitable, immunosuppressive niche for pancreatic islet transplants, and show evidence of safety and efficacy in mice and macaques with type 1 diabetes. 📄: scim.ag/4kdrb7h

🎙can stem cell-derived beta cells cure diabetes? In this episode, Dr. Raphael Scharfmann (Inserm) & Valeria Sordi (San Raffaele) unpack how close we are, the immune hurdles, & why scale matters. 🎧 Listen now 👉 easd.org/media-centre/p… #diabetes #betaCells #T1D #podcast

Most genetic variants are assumed to influence disease risk by effects on gene expression. While most variants can affect the expression of multiple genes, existing methods map a single gene at a time. Clustering the expression of neighboring genes can improve eQTL discovery👇

.Stanford Medicine researchers present a mechanism wherein Desert hedgehog, secreted from epithelial #neuroendocrine cells, elicits a regenerative/protective response from mesenchymal cells. 🖨️ There is study is now available in Cell: bit.ly/3ZTjRFS

siRNA stability and efficacy are improved by a backbone modification go.nature.com/3SBGRWf rdcu.be/erfhx

Gene editing pioneer David R. Liu discusses baby K.J. Muldoon, the first person treated with a customized gene editing therapy, what made K.J.'s treatment possible, and how on-demand treatments for rare genetic diseases could one day become routine. broad.io/DLQA

A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient dlvr.it/TLfp6Q

Excited to share our new research on the metabolic maturation of stem-cell-derived islets upon murine engraftement. Published today in Diabetologia: link.springer.com/article/10.100… OtonkoskiLab Timo Otonkoski Katajisto Lab MetaStem University of Helsinki #SCislet #betacell #diabetes

Congratulations!! Great work by Eliisa Vähäkangas and team! 👏👏

1/ Why is Ki-67 called Ki-67? And why am I attaching a photo of this beautiful city to the tweet? If you work in pathology or oncology, you’ve likely come across Ki-67 many times. But where does the name come from? A short 🧵 on the origins, function, and significance of Ki-67.

Nature research paper: Range extender mediates long-distance enhancer activity go.nature.com/3G6nPo8

A multimodal conversational agent for DNA, RNA and protein tasks nature.com/articles/s4225… 🧬🖥️🧪 huggingface.co/InstaDeepAI/Ch…

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in Nature Metabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n

🎉 Thrilled to share our latest paper in Nature Methods on GeneAgent, a next‑generation AI agent designed for gene‑set analysis with built‑in self‑verification against biological databases to minimize LLM hallucinations. 🔬 Key Highlights 📍 Gene‑set analysis helps researchers

🚨Paper alert!!🚨 I am proud to announce that my postdoc work is now published in Cell Metabolism. HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes cell.com/cell-metabolis…

New application note from R&D Systems showcases efficient, reproducible generation of iPSC-derived pancreatic islets based on our 2021 Nature Protocols paper. High purity (75–80% C-peptide+/NKX6.1+) & robust glucose-stimulated insulin secretion rndsystems.com/resources/lite… #T1D

In the latest issue! Digital reconstruction of full embryos during early mouse organogenesis dlvr.it/TMfXvW

Base editing of β0 thalassemia mutations as a therapeutic strategy for β-hemoglobinopathies: efficacy and genotoxicity studies biorxiv.org/content/10.110… #biorxiv_genetic

Applied Computational Genomics Course at UU: Spring 2024 github.com/quinlan-lab/ap… by the almighty Aaron Quinlan, author of bedtools and many other great tools for genomics analysis.