#LatestPublication Sahil Lall and team from Dr Shachi Gosavi's lab explore the conformational dynamics of the transmembrane domain of SARS-CoV2 spike protein to understand its role in viral fusion. Read Here: bit.ly/3DuzKKJ 🎉Congratulations to the team!

Multiscale MD simulations show that the SARS-CoV-2 spike transmembrane domain is dynamic Living Machines-NCBS National Centre for Biological Sciences Sahil Lall pubs.acs.org/doi/full/10.10…

There are thousands of academic journals, and these numbers involve many assumptions. But, the global OA burden was around 5% (3.5 to 7%) in 2019 $1 bn of the total scholarly publishing market $28 bn

Benny Shilo was an old friend of National Centre for Biological Sciences

A landmark structure resolved the post fusion structure of the coronavirus spike protein. We discuss it in the broader structural context and posit the relevance of the resolved helical hairpin in membrane penetration and fusion. rdcu.be/ethv7

A landmark structure resolved the post fusion structure of the coronavirus spike protein. We discuss it in the broader structural context and posit the relevance of the resolved helical hairpin in membrane penetration and fusion. rdcu.be/ethv7

A harpoon like fusion domain holds the host membrane while the virus fuses with the host. How does the fusion domain engage and insert into the host cell membrane? How is the fusion harpoon stabilized? How is the harpoon stored before it can be deployed? pubmed.ncbi.nlm.nih.gov/40555792/

"...analysis found that his institution [Harvard University] publishes 3.6% of the global output of top life science papers..." [a list of 15 journals including Cell, Nature and Science]

Many Chinese researchers have received enviable benefits and positions after returning from training abroad go.nature.com/3GVB7nL

Is #scitwitter back!? Perhaps in the form of #SciX, #SciEx, #6? My feed on X has improved a lot over the past few days. I welcome this change wholeheartedly.. thanks to X for this positive change!

"Science becomes a lottery where tenure is the prize, truth an afterthought."

Despite chasing single pass transmembrane helices (spTMHs) for a bit, it was a very strange observation 👇 The spTMHs of class I viral fusion proteins are longer than those of other proteins. Preprint below biorxiv.org/content/10.110…