If you're interested in studying TET protein function in vivo, check out the new protocol from sam ross for the generation of F0 zebrafish tet1/2/3 CRISPants. We also include a detailed section on 5mC analyses by RRBS. Protocol can be downloaded here: bit.ly/3oZ1KdX 1/3

Happy Monday! 🧬a reminder from us to you, that our upcoming episode with Ozren Bogdanovic is out on Wednesday at 10AM BST, and we discuss non CG methylation and the other amazing work by Ozren, sam ross & Alex de Mendoza & more. #genomics #epigenetics

Pleased to share the latest review from our lab! We discuss the diverse repertoire of CpG island 🏝 gene regulatory functions and the functional conservation of CGIs in metazoans. Check it out here: doi.org/10.1042/BST202… Ozren Bogdanovic Garvan Institute of Medical Research UNSW Biotechnology & Biomolecular Sciences Portland Press

Thrilled to announce that our manuscript describing the evolutionary conservation of TET-mediated DNA demethylation of regulatory loci during non-vertebrate embryogenesis is now on bioRxiv: tinyurl.com/2yuz4sss Ozren Bogdanovic Garvan Institute of Medical Research UNSW BIOM Stazione Zoologica Anton Dohrn 1/10

Check out our new review published in Cancers MDPI summarising recent research on targeted therapies for the deadly childhood brain cancer Diffuse Midline Glioma. We cover a broad range of promising targets and discuss their future clinical potential. mdpi.com/1402650

Our latest paper is out in Molecular Therapy! We uncovered 3 miRNAs that sensitised #neuroblastoma to chemotherapy. A wonderful collab between Garvan Institute of Medical Research and Childrens Cancer Institute funded by The Kids' Cancer Project doi.org/10.1016/j.ymth…

The comprehensive atlas of developmental regulatory elements in zebrafish is published today in Nature Genetics nature.com/articles/s4158…. In addition to the BioRxiv submission x.com/daniocode/stat… in this paper we added further resources and results. (1/n)

I am happy and proud that our DANIO-CODE DANIO-CODE paper is finally out in Nature Genetics Nature Genetics! I wish to say thank you to everyone who helped and supported our work up until now, with the hope we can continue to deliver in the future as well! nature.com/articles/s4158…

#AGTA22 #AGTA2022

1/ Delighted to share our Immunity publication (out today!) detailing how GOF STAT3 mutations dysregulate CD8 T cells and actively drive pathology in leukemias and autoimmune diseases. authors.elsevier.com/sd/article/S10…

Our manuscript describing 5hmC-mediated DNA demethylation of regulatory loci during non-vertebrate embryogenesis is now out in Science Advances science.org/doi/10.1126/sc… Ozren Bogdanovic Garvan Institute of Medical Research UNSW Centro Andaluz de Biología del Desarrollo

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species biorxiv.org/cgi/content/sh… #bioRxiv

Now out in @NAR_Open academic.oup.com/nar/advance-ar…

DNA methylome remodelling in medaka & medaka-zebrafish hybrids out now Nucleic Acids Res academic.oup.com/nar/advance-ar… Garvan Institute of Medical Research Sydney Uni Life&Env Centro Andaluz de Biología del Desarrollo IMP Vienna BioCenter Juan R. Martinez-Morales Alvaro Gonzalez Rajal Marcel Dinger Javier Vazquez-Marin @PauliGroup @kristagert Ozren Bogdanovic

🚨Excited to share our preprint! A promising epigenetic combo therapy targeting FACT and BRD4 in DMG. Shoutout to Dr Aaminah Khan for co-leading this with me, and to Dr Maria Tsoli and Prof David Ziegler for their mentorship! Childrens Cancer Institute #Epigenetics #DMG biorxiv.org/content/10.110…