MetNet hosts an epic "AMPK vs. mTORC1 Battle for Metabolic Supremacy" with Reuben Shaw and Brendan Manning WWE style. After 3 grueling rounds, "Hacksaw Shaw" and "The Hit Man Manning" tie for the belt! D.Guertin, K.Shen, D.Kim MC with style...

🚨Paper alert🚨 in #MSI and #tumormetabolism. Want to see metabolic tracing at single organelle resolution? Excited about spatial metabolic flux analysis? Want to know why your tumour likes an energy drink as much as your teenage children? Read on! nature.com/articles/s4225…

Our Journal of Biological Chemistry review on the regulation of 1C metabolism is now out. Check it out (or at least the figures :) ) Kanarek.Lab doi.org/10.1016/j.jbc.…

Looking for #Research Assistants (I or II depending on experience) to help establish the new Tsvetkov lab in BIDMC Cancer Center BIDMC Pathology . Great opportunity to help do exciting science on the interphase of cancer, metabolism, and metal biology. Please RT. links below

***New Paper***** Kanarek.Lab: Is this early, aberrant erythroid differentiation induced by folate depletion part of a molecular mechanism of nutritional anemia? check it out - Out today in Science Advances science.org/doi/10.1126/sc…

Thrilled to share a new lab preprint spearheaded by superstar postdoc Apoorva Uboveja in collaboration with Nathaniel Snyder! We discovered something totally unexpected – aKG is important for histone acetylation! biorxiv.org/content/10.110…

Excited to share our new paper out in PNASNews pnas.org/doi/10.1073/pn… on cysteine susceptibility in #glioma. This was a long effort over years with Cantley Lab @Lnpalma Isaiah Yim Nayah Bullen Daniel Barnett Jan Krumsiek Olivier Elemento among others Weill Cornell Neurology Weill Cornell Medicine Meyer Cancer Center

A second-generation degrader of the enzyme AKT—a key supporter of cancer cell proliferation and survival—can deplete AKT and halts breast cancer cell growth, especially in cells with basal JNK kinase activity. @alex_toker BIDMC scim.ag/6a1

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in Science Magazine. Huge congratulations to co-first authors Umakant Sahu and Elodie Villa! science.org/doi/10.1126/sc…

Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and Maria Weyh! Congrats Maria Weyh @ML_Jokisch Max Fottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 Kathrin Lang nature.com/articles/s4155…

We are delighted to share the #tyrosine The Kinase Library, now in nature: nature.com/articles/s4158… Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org #TheKinaseLibrary #KL #part2 🧵 1/9

Happy to share the first preprint from the lab! We describe how extracellular lipid availability regulates a polyunsaturated fatty acid trafficking pathway in cancer cells that influences ferroptosis sensitivity. Check it out! 👇 biorxiv.org/content/10.110…

Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.110…

*New paper alert* I’m happy to share our latest study, out this week in Nature Communications. Led by former postdoc Nate Ward (who now leads his own lab at Moffitt Cancer Center), we asked how mitochondria cope with cystine starvation. nature.com/articles/s4146…

FOR THE LOVE OF PURINES: We are truly excited to share our latest work Cell Press on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors.cell.com/cell/fulltext/…

New preprint from the lab is online! The product of a stellar collaboration with Muir Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/

New study from our lab and Hans Widlund in Cell Reports mapping the metabolic routes of the sulfur amino acid cysteine establishing melanoma epigenetic states maintained by lysosome function, conferring resistance to ferroptosis and metastasis shorturl.at/29erU

My first author paper from my thesis work has been uploaded to BioRxiv! We identified Mecr as important for T cell fitness in in vivo CRISPR screens. I have further worked with Mecr and am the first to show it regulates T cell function and metabolism. biorxiv.org/content/10.110…

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

UVM, partnering with BioLabs, will join an elite group of universities which currently house on-campus incubators, with the launch of a startup incubator for life science research at UVM’s Colchester facility. ⬇️ uvm.edu/news/ovpr/univ…