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A simplified definition of a statin-eligible primary prevention patient is one who is: • 40–70 years old w/ LDL-C ≥ 3.0 mmol/L or • 55–80 years old with LDL-C ≥ 1.8 mmol/L & additional risk factors 💊 ow.ly/K6vm50Vhffm EJHF Editor-in-Chief Jan Biegus #HFA_ESC #ESCHeartFailure

Although weight loss in people with #obesity has many health benefits, it can also have adverse #skeletal effects, with increased #bone loss and #fracture risk thelancet.com/journals/landi… #BMD #osteoporosis #weightloss #BariatricSurgery #GLP-1 receptor agonists

Semaglutide flips the brain's hunger circuit! Fasting activates AgRP (hunger) neurons and silences POMC (satiety) cells. #Semaglutide boosts POMC activity while suppressing AgRP signals, triggering lasting fullness! #Neuroscience #WeightLoss #GLP1 academic.oup.com/endo/article-a…

2 important papers nature today indicate the potential for #AI to improve diagnostic accuracy and overall clinical performance for patient management and interactions Google DeepMind Vivek Natarajan Daniel McDuff Tao Tu Alan Karthikesalingam nature.com/articles/s4158…

Understanding adherence rates with and discontinuation of GLP-1 medicines -here higher out of pocket costs for GLP-1 meds were associated with reduced adherence and increased rates of adverse outcomes among type 2 #diabetes patients Diabetes Care, a research journal of the ADA 🌟 diabetesjournals.org/care/article-a…

#HighlyViewedPaper Vitamin D in Diabetes: Uncovering the Sunshine Hormone’s Role in Glucose Metabolism and Beyond by Jie Wu and Annette Atkins et al. Welcome to read: mdpi.com/2072-6643/15/8…

Overview of clinical evidence for sex-specific effects of GLP-1 analogs and their potential interaction with estrogens. GLP-1 analogs are reshaping diabetes and obesity care, but sex differences in their effects are emerging. Women may experience distinct benefits and side

New in the May Issue: Type 2 #diabetes and accelerated #ageing in skeletal #muscle thelancet.com/journals/landi… #T2D

In the May Issue: The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/landi… #osteoporosis #BMD #fractures #BoneHealth #incretins #GLP-1 receptor agonists

Unravelling the GIPR agonist versus antagonist paradox go.nature.com/3Gu8UDU

🌀 GLP-1s can have confusing and frustrating gastro side effects, as patients can experience constipation, diarrhea, or even both! Watch 𝗚𝗲𝘁𝘁𝗶𝗻𝗴 𝗦𝗼𝗰𝗶𝗮𝗹 𝗔𝗯𝗼𝘂𝘁 𝗖𝗼𝗻𝘀𝘁𝗶𝗽𝗮𝘁𝗶𝗼𝗻 to help them get relief! ➡️ ms.spr.ly/6019S6cDb

Evaluating bone turnover, mineralization, and volume of patients with chronic kidney disease can guide the approach to preventing fractures. Read more in #EndocrinePractice: endocrinepractice.org/article/S1530-… Vin Tangpricha, MD, PhD Elsevier Endocrinology & Diabetes #endocrinology

To mark the 30th anniversary of #EndocrinePractice, each 2025 issue features a retrospective on topics covered in 1995 and the progress achieved since then. April 2025: Management Aspects of Medical Therapy in Graves’ Disease endocrinepractice.org/article/S1530-… Vin Tangpricha, MD, PhD Elsevier Endocrinology & Diabetes

Most viewed this week from JAMA: Between 2021 and 2024, semaglutide and tirzepatide prescriptions in Epic-affiliated health care systems increased slightly but remained limited, with only 3% of eligible patients receiving them. ja.ma/3ERX6uC

Wonderful ! Tirzepatide A win-win for weight & muscle health! Dr. Shashank Joshi Dr. Om Lakhani, MD, DNB (ENDO) Dr M V Rama Mohan Anish Kar Karthik Balachandran Dr. Deep Dutta Dr Nitin Kapoor Dr Abhijit Bhograj Shashi Advanced Health Mushtaq Bilal, PhD Dr.Shinjan Patra DM Endocrinology Endocrine Society of India Vinaykumar Hallur MBBS MD FECMM DR AMIT GOEL Dr Parth Jethwani, MD, DM Endocrinology Euro J Endocrinology

This review examines recent findings on the prevalence, diagnosis, and implications of sarcopenic obesity, explores the effects of weight-loss interventions on body composition and their impact on health, and discusses strategies to preserve muscle mass.

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵

Very happy to see the lively interest re rare bone diseases European Society of Endocrinology (ESE) : presentation of the novel guidelines of X-linked hypophospataemia

NEW STUDY: People who consistently do vigorous exercise have slower rates of epigenetic aging compared to those who don't. Light to medium activities don't cut it tinyurl.com/k552u4my

Nutritional priorities to support GLP‐1 therapy for obesity ⁦The Obesity Society⁩ ⁦Obesity Medicine Association⁩ ⁦Fatima Cody Stanford MD MPH MPA MBA FAAP FACP FAHA⁩ ⁦Monica Agarwal MD, MEHP, FACE⁩ Finally we have a plan for #obesity with meds, lifestyle and everything onlinelibrary.wiley.com/doi/10.1002/ob…