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📢New Study in Print #Transferlearning in a biomaterial #fibrosis model identifies in vivo #senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. link.springer.com/article/10.100… Johns Hopkins Medicine Mayo Clinic

Congratulations to Dr. Soham Ghosh (Soham Ghosh) for receiving the U.S. National Science Foundation CAREER award for his mechanobiology research! 🎉 Read more about the research his lab group is doing here: buff.ly/3Mv0uLY

"Patchiness" in Mechanical Stiffness across a Tumor as an Early-Stage Marker for Malignancy biorxiv.org/content/10.110…

Congrats to Lauren Paschall for her first pub on the sex-specific mechanobiology of ACL explants! Very exciting work suggesting a novel mechanobiological mechanism for increased ACL ruptures in women. Erdem Tabdanov Aman Dhawan Penn State Biomedical Engineering PennStOrtho pubmed.ncbi.nlm.nih.gov/37602554/

Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic ... biorxiv.org/cgi/content/sh… #biorxiv_cancer

Thoroughly executed work by Samantha Wilkins and other coauthors in our lab on Mesenchymal Stromal/ Stem Cell Population heterogeneity is now published in Advanced Biology. It is open access. Our lab's first independent paper on MSC. onlinelibrary.wiley.com/doi/10.1002/ad…

.Soham Ghosh reports that #MSC population becomes phenotypically heterogenous and commits to an unwanted osteoprogenitor pathway when it experiences an abnormal mechanically stiff environment, compared to its native softer environment. 🔓 Learn more: onlinelibrary.wiley.com/doi/10.1002/ad…

Dig into the role of 🧬 #epigenetic machinery in fate decision and functional properties of MSCs! 📖 The authors summarize the current understanding of the role of epigenetic control of MSC differentiation and immunomodulatory properties. CDD press | bitly.ws/ZBwY

Primarily executed by two undergrad students, in this preprint we show that chromatin has a role in cell migration. biorxiv.org/content/10.110…

A new preprint from our lab focuses on a key biological inquiry: emergence. PhD candidate Eric developed an elegant framework that integrates dynamic mode decomposition and optimal control, demonstrating the coordinated migration of cells. biorxiv.org/content/10.110…

Humbled to see this paper by Samantha Wilkins as top 5 accomplishments in 2023 picked by Mesenchymal Cell News STEMCELL Technologies news.

Wrapping up 2023 with a new preprint from our lab. We investigated how too much oxygen affects the chromatin architecture. Contributed by several lab members, especially Lauren Monroe. biorxiv.org/content/10.110…

nature.com/articles/s4200… High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy. Another application of holotomography Biomedical Optics Laboratory KAIST TOMOCUBE, INC.

Friends don't let friends make bad charts! Chenxin Li, pulled together a lot of great advice for data visualization, with clear "do this, not that" examples for each item. Here are a few of my favorites, see the link below for more.

Excited to share the first spatially resolved multiomics atlas for human bone marrow, published today in Cell. twtr.to/cJ099. Wonderful collaborations with Ling Qin Ling Qin, Charles Nelson, Martin Carroll, Ivan Maillard, Vinohd Pillai HemepathMD labs!

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

New paper in Nature Communications! Our joint theory and Hi-Res imaging study shows how inhibiting transcription alters 3D chromatin organization by reducing loop extrusion thus increasing the size of heterochromatin domains in multiple cell lines. nature.com/articles/s4146…

Some of us were asked by Cell about the future of mechanobiology. In all likelihood, 20 years from now we'll see we were all wrong. Any thoughts? What did we miss?🤔🔮👇authors.elsevier.com/a/1j8Ml_278y%7…

How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by Grace Bower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/

REGISTER NOW 📆 C-Path's Predictive Safety Testing Consortium is delighted to announce its second public workshop on evidentiary considerations for regulatory assessment and qualification of complex in vitro models - CIVMs.i.mtr.cool/gnexkradpd