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Hello everyone, please check out our preprint paper 🥰 I appreciate Dr. Nakamura, Dr. Otani (Tetsuhisa Otani), Dr. Togashi, and all helping members.

Issue 19 is complete Explore our ToC here: journals.biologists.com/jcs/issue/137/… On the cover: expansion microscopy image of four Toxoplasma gondii parasites showing the apical polar ring (green) and microtubules (magenta) from @LuiAriasPadilla, Jonathan Lopez, et al. journals.biologists.com/jcs/article/13…

Also in Issue 19: - Research Highlights on microtubules in neurons and Toxoplasma, KIF1A autoinhibition and regulation of epithelial junctions - Erythroblast enucleation at a glance - Review on HIV-1 assembly journals.biologists.com/jcs/issue/137/…

Congratulations The Milinkovitch-Tzika lab for your latest publication in Current Biology : Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses Genetics & Evolution Faculty of Science | UNIGE 👉Full text: sciencedirect.com/science/articl…

Graphical abstract for The Milinkovitch-Tzika lab latest publication on dogs, furrets and cows noses 🐶🐮 Genetics & Evolution

Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta Chandni Bhickta nicolas chiaruttini & in co. with @burnsajohn is finally out nature . Link⏩: nature.com/articles/s4158… Preprint⏩: biorxiv.org/content/10.110… 1/5)

Congratulations to Dr. Marine Mauperin, from Citilab, Who brilliantly defended her PhD thesis last Friday!!!🍾🥂👏👏👏💪💪...many thanks also to the Thesis Jurors Profs Laurent Blanchoin, Sophie Martin and Bernhard Wehrle-Haller. Ad majora! 🙏🍾🥂

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics | Nature Communications Check out this outstanding piece of work by Marine Mauperin in my lab! nature.com/articles/s4146…

2. It all started with the question: is the uncoupling of gamma actin from TJ involved in any of the phenotypes of CGN-KO cells? Marine made gamma actin-KO MDCK cells and saw the (expected) up regulation of beta (actin)

3. But, in addition, Marine noted that nonmuscle myosin2A was also increased and (!!!) by depleting NM2A the increase in beta was reversed!!! A mechanosensing feedback circuitry!!!

4. Gamma-actin KO cells showed increased TJ membrane tortuosity, and depletion of NM2A rescued this mechanical phenotype of the TJ membrane cortex. So, it's increased NM2A that makes TJ more tortuous!

5. Thanks to our great collaborators in the lab of Jie Yan (Singapore) and Andreas Janshoff (Göttingen)we could also show decreased apical cortical stiffness, similar to CGN-KO cells. So, gamma-actin is required to keep the apical cortex stiff!

6. Fluorescence recovery after photobleaching showed that both CGN and ZO-1 are more dynamic in gamma actin KO cells: so, actin isoforms regulate the dynamic of junctional proteins!

The greatest team of all celebrates Marine Mauperin's publication on Nature Communications!🥇🥂🎈🎉🎊👍👍👏👏💪💪

Congratulations Citi Lab for your latest publication in Nature Communications A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls #tight #junction and apical cortex mechanics unige.ch/medias/en/2025… Molecular & Cellular Biology Dept 🔬 Geneva 🇨🇭 Faculty of Science | UNIGE

The fine control of cell mechanics - Medias - UNIGE unige.ch/medias/en/2025…

In our interview with Jennifer Lippincott-Schwartz Lippincott-Schwartz Lab, we discuss her research career, her advice on building collaborations and learn why she is looking forward to #biologists100. Jennifer will be speaking in our emerging technologies session. journals.biologists.com/jcs/article/13…

L’hypertension artérielle est l’un des principaux facteurs de risque de maladies cardiovasculaires🫀. Des scientifiques de l’UNIGE se sont penché-es sur le rôle d’une protéine, la paracinguline, dans cette maladie. Leur récente étude🔬met en lumière sa contribution déterminante

Congratulations Citi Lab for your latest publication! Faculty of Science | UNIGE Molecular & Cellular Biology Dept 🔬 Geneva 🇨🇭

Paracingulin controls the junctional accumulation of nonmuscle myosin-2 in endothelial cells in vivo doi.org/10.17912/micro… Great little paper validating our insights (JCB 2023) about the role of cingulin family proteins in cytoskeleton organization at junctions!