Interesting work from our lab alumnus Srivastav Ranganathan on RNA-binding protein condensates and emergence of fibrillar structures using coarse-grained simulations.

youtu.be/v68zYyaEmEA Wordle and information theory!!!

Our work, modeling the high fidelity inheritance of histone modifications post replication, using ideas from information theory, is published in PLOS computational biology. journals.plos.org/ploscompbiol/a… Ranjith Padinhateeri

This reminds me of a video that we - @sangramjkadam Navin Sridhar and I made a looong ago in our undergraduate years using a stop motion animation! Just a camera setup in the hostel room. Here is the link.. youtu.be/ukuiGlHx-wI

Chromatin is modelled as a bead-spring polymer. But how big is(physical size) a 10kb or 100kb chromatin bead? How flexible/bendable is chromatin? Starting nucleosome resolution, we coarse-grain chromatin & predict scale-dependent properties biorxiv.org/content/10.110… @sangramjkadam

Congratulations to Prof. Ranjith Padinhateeri for being elected as a Fellow of the Indian Academy of Sciences, Bengaluru.

Our work is out in Nature Communications. Read the paper if you want a quantitative description of chromatin polymer or plan to simulate chromatin. We answer some fundamental questions. Details below. @sangramjkadam Kiran K. Vinoth Shuvadip Dutta mithunmittir (1/10)

Happy to share our latest preprint where we explore how the clustering of enzymes can improve metabolic fluxes even when the enzymes themselves are far from "perfect". biorxiv.org/content/10.110… Work done with Junlang Liu and Prof. Eugene Shakhnovich.

... ... and here is how the Chandrayaan-3 Rover ramped down from the Lander to the Lunar surface.

@iitb4justice stands in solidarity with senior PhD scholars protesting against hostel shifting policy abruptly enforced on the batches severely affected by the pandemic.

"How high-impact papers from Indian researchers are shaping science". nature.com/articles/d4158… One of these from MajiLab (Protein Engineering and Neurobiology Lab) IIT Bombay. Samir Samir K Maji has pioneered work on aggregation & phase separation of proteins associated with neurodegenerative diseases. Biosciences & Bioengineering, IIT Bombay

Our latest paper to wrap up the year. We propose that intersegmental jumps that leverage looped conformations of chromatin can lead to efficient search. Read the preprint at: biorxiv.org/content/10.110… Led by Shuvadip Dutta & Adarshkrishnan. Fantastic collab. with Ranjith Padinhateeri (1/4)

Samir K Maji Biosciences & Bioengineering, IIT Bombay IIT Bombay Congratulations Samir... great going.

What is the role of diffusion of enzymes/other constituents in the spreading of histone modifications? We simulated a model with diffusion and reaction of reader/writer enzymes to explain the spreading of histone modifications. biorxiv.org/content/10.110… (1/5)

Excited to be a part of #BPS2024 and present my work. for details, have a look at our preprint: biorxiv.org/content/10.110… mithunmittir Ranjith Padinhateeri #Philadelphia Biophysical Society