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Your mistakes don't define who you are. It's what you do after you have made the mistakes that makes all the difference. Every mistake you make is a learning experience. They don't make you less capable. But it's how you correct them or learn from them that defines you.

One moment there's nothing, the next... a heartbeat. As a vertebrate embryo grows, its heart tissue starts to pulse well before it's actually needed. But how does the developing heart actually co-ordinate that very first beat?

In a major milestone for science, for medicine, and for patients, the world’s first CRISPR drug has been approved in the UK. “A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory

📢Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy 🧬 Great study led by super-scientist JanaSlyskova in collaboration between @HannesLans and Joanna Loizou labs 👏

Great work by our collaborators and lab neighbors, the Chandwani lab! This paper has been a long time coming and raises a bunch of interesting ideas about susceptibility to oncogenic transformation.

‘Always surround yourself with people who are better than you. Eventually you will become like them’. Beyond thankful for being part of this amazing lab!

ARE METABOLIC ENZYMES ON CHROMATIN? Yes, they are ⤵️! We optimized a chromatin enrichment protocol to improve the extraction of chromatin-bound proteins (chromatome) and applied it to > 140 samples, including cancer cell lines and healthy epithelia from 10 different tissues. 🧵

Great preprint from the Sdelci lab! They analysed the chromatomes of >140 healthy and cancer samples, and show different enrichment of metabolic enzymes on chromatin depending on the tissue type and disease state. Congrats to everyone involved!

Our new preprint describes “CROPseq-multi”: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens doi.org/10.1101/2024.0… Reagents on Addgene: addgene.org/browse/article…

Words make a difference. Whether I'm sending an email to students, staff, or faculty, I start with "Dear Colleagues" No matter what our education background, titles, or job duties, we are all colleagues and should treat each other with the respect inherent in that word.

How to get cancer without DNA mutations, challenging dogma: temporary epigenetic changes nature Nature News & Views nature.com/articles/s4158… nature.com/articles/d4158… just says in flies Classenlab CNRS 🌍 Université de Montpellier InstituteHumGenetics

When a lab submits a study is a day to celebrate! I share here a fantastic story where we unveiled that DNA damage promotes an MDM2-NICD axis with strong clinical implications. See our manuscript for details and don’t hesitate to comment it. Please RT biorxiv.org/content/10.110…

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s4158… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]

The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic & imprecise. Here we dig deeper into the events leading to cancer mortality nature.com/articles/s4156… 1/2

So, it turns out that we now can do Western blot from single cells. Cool ! At least it worked for them in #cancer cells. Full story Nature Communications nature.com/articles/s4146…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

Intelligence isn't the ability to remember and repeat, like they teach you in school. It is the ability to learn from experience, solve problems, and use our knowledge to adapt to new situations.

Sharing this for twitterless (X-less?) Rohit Chandwani - a great clinical dive into differences between KRAS G12D/V and G12R mutations. Mirrors clear differences we see in mice. Happy we could contribute a small part to this work. G12R is an odd duck... sciencedirect.com/science/articl…

10 years old today... the lab is double digits!! Happy birthday to us!

Dow Lab we're looking forward to your presentation at #AMC25 in the Dominican Republic🇩🇴 next February! Please RT to let your followers know Talk Submission closes next week! ✅Register & Submit: bit.ly/3BbtGoY