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Striking example of pseudoangiosarcomatous (acantholytic) urothelial carcinoma. Pankeratin+, Gata3+, p63+, and vascular markers-. #GUPath

🔬 "Fibrosis" ~ Trichrome stain of fibrosis in the renal pelvis of a patient with obstructive nephropathy ~ #PathArt 📷🎨

#GUpath #grosspath correlation: myxoid degeneration in nephrectomy of clear cell RCC 🚨👁️gross & histologic🔬mimic of tumor cell necrosis (an important poor prognostic factor for clear cell RCC)

🔬📷 Diabetic Nodule ~ Takes over glomerulus as a vortex 🌪️ (PAS and Trichrome stains) ~ #RenalPath #Pathology #PathArt

#GUpath nephrectomy for single 4cm renal mass from adult, no priors #LPpath Dx (or Dx'es😉) ❓🔬

This image (Jones silver stain) shows prominent glomerulitis in an allograft kidney biopsy, characterized in this case by increased mononuclear cells and segmental endothelial cell swelling within glomerular capillary loops. The patient is a young adult man who had received a

The light microscopic image depicts interstitial foam cells which, while non-specific and can be seen in longstanding proteinuria, are concerning for Alport Syndrome given the clinical scenario of hematuria and hearing loss. By electron microscopy, diagnostic findings would

#GUpath grading of multinucleate tumor cells in RCC is a bit controversial - some apply WHO/ISUP and render grade 4, others grade 3/descriptive ✅some data but more needed! 🔬to me these are different than "syncytial-type" multinucleate giant cells which I consider bad/grade 4

Fibronectin glomerulopathy 🔸Massive fibronectin deposits 🔸AD mutation FN1 🔸MPGN-like pattern 🔸Silver-neg, PAS+, trichrome-red 🔸EM: Homogeneous granular + variable fibrils 🔸IF/IHC strongly + fibronectin 🔸renal-limited (1/2) #renalpath #PathTwitter

🔬📷 Beautiful section of the Epididymis ~ Can you identify the key areas seen in the image? ☑️ Efferent Ductules ☑️ Head ⭐️ Bonus! A small Appendix Epididymis #GUpath #Histology #Pathology #Testis #PathologyBasics

Today's #eyeSCANdy is a SEM of acellular GBMs from segmental membranous illustrating the variability of size and shape of the GBM formations.  Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath

for the #pathresidents: #GUpath radical prostatectomy for bx-proven 3+4 prostate cancer; patient also has h/o bladder cancer

New in #HumPathol: Invasive urothelial carcinoma with chordoid and myxoid features shows increased RAS/RAF pathway alterations. sciencedirect.com/science/articl… #pathology #PathTwitter #PathX #GUpath

One of the more subtle amyloid cases I have seen. Just a few deposits in 2 gloms by LM. Just enough congo red staining. Glad to catch it in the EM as well. #renalpath #nephrology #pathtwitter

🔬Case of a "Burnt Out" or Regressed Germ Cell Tumor: ➡️ Fibrous scar (middle) with hemosiderin pigment ➡️ Some residual seminoma and GCNIS (left) ➡️ Intratubular calcifications (seen focally on right) #GUpath #Pathology #Testis #TesticularCancer

A sample from the pathology teaching slide set on Minimal Change Disease in Adults, jointly prepared by Arkana Laboratories and KDIGO. KDIGO.org/guidelines/gd/ #KDIGO #pathology #renal #renalpath #pathx #pathtwitter

Our article on high-grade prostate cancer in young patients is available online journals.lww.com/ajsp/abstract/… Katrina Collins, MD || Pathologist Daisy Maharjan International Society of Urological Pathology GU Pathology Society (GUPS) USCAP IUPathology BDIAP

#GUpath radical nephrectomy for RCC grossly encroaching renal pelvis: is top vs bottom row pelvicalyceal invasion (PCI; which is latest pT3a addition to AJCC staging)? and what constitutes PCI? in👇🏼interobserver study, Sean R Williamson MD & I explore this, offering our $0.02

#GUpath orchiectomy for germ cell tumor grossly encroaching hilum: should top vs bottom row be considered "hilar soft tissue invasion" (HSTI)? HSTI=pT2, so critical staging parameter! how should HSTI be defined? in👇🏽interobserver study, we investigate this and offer some💡

🔬 Can you identify this renal tumor in this low power view? Or is it #TooLowToDiagnose? #GUpath #Pathology #Kidney #KidneyTumors