🆕 EMA approves vimseltinib for symptomatic symptomatic tenosynovial giant cell tumour (#TGCT) 🎯 Oral CSF1R inhibitor for pts w/ functional decline & no surgical options 📈 Ph. 3: improved ORR, durable responses at week 97 #Sarcoma field expands—turns out targeting CSF1R

For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in Science Magazine, researchers from the Patrick Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.

Today in Science Magazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The

Over the past week, Arc Institute published three new discoveries that I’m very proud of. • The world's first functional AI-generated genomes. Using Evo 2 (the largest biology ML model ever trained, which Arc released in partnership with NVIDIA in February), Arc scientists

The #SARCTrials Multidisciplinary Tumor Board features experts across #oncology collaborating to discuss challenging #sarcoma cases. Together, we’re shaping better care pathways for patients. 👉Physicians submit a case here: sarctrials.org/sarc-tumor-boa…

🧬 Building the Virtual Cell starts with data. Today, we’re making the X-Atlas/Orion Perturb-seq dataset even more accessible — now live on Hugging Face Hugging Face 🤗 📊 One of the largest & highest-quality perturbation datasets ever released, it provides the foundation for

Our latest #MemberBlog from #SPAGN member, Cédric Bochsler of the Shane Osteosarcoma Association, writes about his family's journey and their work to honor their son Shane across the global sarcoma community. Read + share: sarcoma-patients.org/blog/founding-… #BoneSarcomaAwareness #Sarcoma

Join us at 9:00 AM ET on Monday, November 3, 2025, for the upcoming live expert discussion about circulating tumor DNA (ctDNA) in sarcomas. Submit any questions you have in advance or use the Q&A feature during the event. You can also share questions on social media anytime

MetaGraph: Searching the world’s DNA at petabase scale Modern biology is drowning in data. Public sequencing archives now hold more than 67 petabases of DNA and RNA—yet, paradoxically, most of it is beyond search. Finding a gene, variant, or viral fragment across this ocean

Many people think of proteins as having a biological function — catalyze reactions, detect pathogens, etc. At a higher level, though, proteins are programmable materials. They are an advanced form of nanotechnology, made from templates that we can read and write and understand.

The Baker Lab designs protein on/off switches 1/🧵 Instead of optimizing for how tightly a given protein binds to a target, Adam and team develop a method to control the duration of binding.

An exciting milestone for AI in science: Our C2S-Scale 27B foundation model, built with Yale University and based on Gemma, generated a novel hypothesis about cancer cellular behavior, which scientists experimentally validated in living cells.  With more preclinical and clinical tests,

We’re building tools to support research in the life sciences, from early discovery through to commercialization. With Claude for Life Sciences, we’ve added connectors to scientific tools, Skills, and new partnerships to make Claude more useful for scientific work.

Claude can now connect to Benchling, PubMed, and Synapse.org, among other platforms. And our new Agent Skills can help Claude follow scientific protocols and procedures consistently.

‼️🆕 Just published in JAMA Oncology: Consensus guidelines for the use of #NGS in #sarcoma pts: 🤔Little data supporting routine, nonselective use 🔬💊Potential benefit in selected entities 🏥Sarcoma experts are critical 🧬BUT we need more molecular data! ▶️jamanetwork.com/journals/jamao…

César Serrano García JAMA Oncology Robin Lewis Jones Paolo G Casali SPAGN William Tap Paolo Dei Tos Piotr Rutkowski Silvia Stacchiotti ANASTASIOS KYRIAZOGLOU CTOS Andrea Napolitano Important guidance for real world practice 👏 NGS isn’t one size fits all in sarcoma but when used selectively, it can unlock targeted options and better clinical decisions. More molecular data will help move precision medicine forward. #ESMO25 #Sarcoma #NGS #PrecisionOncology

We're partnering with Google Research to kick off a new series of Featured Notebooks exploring topics ranging from health to science to (of course) AI. Starting with "How do scientists link genetics to health" this notebook explores some of what we've learned over the past 10

On #SARCTalk, Dr. Elsa Keeler — retired #pediatrician, #chondrosarcoma survivor, and fierce #advocate shares her inspiring journey from #medicine to #activism. Learn how she’s making an impact with @ReinInSarcoma and #SARCTrials. Listen now: open.spotify.com/episode/2fEK4s… #sarcoma

Less than one week until our next Live with the Experts! Join us Monday, November 3, at 9:00 AM ET for an expert-led discussion on circulating tumor DNA (ctDNA) in sarcomas. Submit your questions in advance or use the Q&A feature during the event. You can also share questions

Big news - today we are announcing that NVIDIA is working with Eli Lilly and Company to launch the world's largest Biopharma AI Factory. Built on over 1000 Blackwell Ultra GPUs, the AI factory will support applications across the entire R&D value chain including drug discovery,