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Had an awesome time at #OCBS2023 at #uofguelph! Thanks to the organizers @DR_SSFS Costin Antonescu et al. Here’s some #sickkids representation 👇with Jim, Ava and Guillermo and congrats ava on winning an award!

Please re-tweet! We're searching for a Drosophila lab technician! Interested in Drosophila as a model to study metabolism & lipid biology? Please DM for details. Ideal position for recently graduated undergraduates interested in research experience prior to grad school.

Defining the EM-signature of successful cell-transfection biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Congratulations Raffaella De Pace Saikat Ghosh Juan S. Bonifacino 🎉 Wonderful to see this exciting work published!

From deep brain stimulation to the cellular biology of rare neurological conditions, Toronto’s leading scientists from #SKResearch and Krembil Brain Institute came together earlier this week to discuss promising research in #neuroscience & #MentalHealth at the first ever #Neuronto symposium 🧠

Thanks for covering our work!

Cells sense high lysosomal membrane tension - as can happen in some lysosomal storage disorders - and activate transcriptional programs to help tissues deal with this stress. Huge congratulations to Ruiqi Cai Spencer Freeman and others! rdcu.be/dNyYD

Sina, Aleixo Muise and I are thrilled to share our paper on mechanisms that nucleate adhesion structures in macrophages. They involve the tyrosine kinase Syk which bridges ITAMs via its tandem SH2 domains. Great having this in The Journal of Immunology The American Association of Immunologists (AAI) journals.aai.org/jimmunol/artic…

Interested in podosomes? This #JI_TopRead identifies regulators of podosome formation. Discover the key signaling events by reading this study by S Ghasempour, Aleixo Muise, & Spencer Freeman: ow.ly/JAIV50TFWFk. #ReadTheJI #immunology

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Now published, SHUBHAM SINGH identifies PLD3/4 as synthesizing BMP, a lipid crucial for #lysosome #lipid #metabolism and #brain health sciencedirect.com/science/articl…

One of the most inspiring talk #FromCelltoOrganism2024 @sbcf1 SFBD-BioDev was given by Spencer Freeman Spencer Freeman The Hospital for Sick Children (SickKids) on #lysosomes

Amazing work from the lab of my friend and colleague Johnathan Canton describing antigen escape from phagosomes via apolipoprotein, enabling cross-presentation. Congrats to all 👏👏

What a great autophagy review from the lab of my friend & colleague @Charly_Guardia ! Check it out 👉Autophagy in reproduction and pregnancy-associated diseases: iScience cell.com/iscience/fullt…

Tons of great talks today at #CellBio2024, with a special shoutout to some of my favourites by Saikat Ghosh & @Luis_BonetPonce 👏👏 Pun-tastic chairing by the great @PSKCellBio 😂👌

New PI position at SickKids for people interested in neural and glial mechanisms of cognition. Please share widely and apply! Science Careers - jobs.sciencecareers.org/job/668484/sci… Nature Careers -  nature.com/naturecareers/…

Out today in Science Magazine! We show that rising self-antigen levels during infection give self-reactive T cells an opportunity for enhanced TCR signalling. Regulatory T cells of matched specificity counteract this, thereby preventing autoimmunity. buff.ly/3EXaXQa

A really cool review on lysosomal stress & damage 👏

Pemberton, Burke, Balla NICHD News et al report the generation & characterization of an engineered active fragment of PIKfyve and its use to generate extra PI(3,5)P2 in endomembrane compartments & test the function of PI(3,5)P2 #biosensors hubs.la/Q03dyfL60 #lipids

We’ve engineered stable cell systems to induce lipid scrambling of the plasma membrane with active forms of TMEM16F. Scrambling alone causes vesiculation (🔵TMEM16F; 🟠PS/Annexin V). Let us know if you want to try the cells out. Preprint: biorxiv.org/content/10.110…