🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

What an exciting story!

We are searching for a highly motivated PhD student (m/f/d) interested in developing novel CRISPR 2.0 gene editing technologies for CAR-T cell engineering and cancer immunotherapy Universitätsklinikum Würzburg & Universität Würzburg #UniWürzburg. Please RT 🙏.

Our study on the effects of metal ion concentration on Cas12a specificity is now out as a Breakthrough Article in Nucleic Acids Res! Congrats to Ginny Giang Nguyen, Michael Michael Schelling and all the authors!

Alexandra Paulk et al. have upgraded OrthoRep-driven antibody evolution by installing a rapid induction system for yeast display and new error-prone DNAPs for faster in vivo antibody diversification. Much more in this space soon! pubs.acs.org/doi/10.1021/ac…

We are hiring UC Irvine, a tenure-track faculty member at the Assistant or Associate Professor level with expertise in any area related to RNA biology, including microbiology, oncology, virology, structural biology, chemical biology, and genomics. recruit.ap.uci.edu/JPF09320

🥳Today pnas, we reported CRISPR-Translate, a genome-wide CRISPR-Cas9 knockout screen-based method designed to identify factors regulating translation. We discovered IRF2 as a novel regulator of OAS3/RNase L-mediated RNA decay during viral infections. pnas.org/doi/10.1073/pn…

Our work describing extensive gene divergence on laboratory timescales with upgraded OrthoRep systems is now out in Science Magazine here - science.org/doi/10.1126/sc…. X thread describing the preprint is quoted below. Congratulations to Gordon Rix and team!

ABE8e: the Beyoncé of base editing—flawless dimerization, exclusive interactions, and unparalleled efficiency! 🎤 Check out our latest work: doi.org/10.1093/nar/gk… Giulia Palermo Audrey Lapinaite Souvik Sinha Aakash Saha #CRISPR #BaseEditing #ChemComp #MDsimulations

Do you want to know why hashtag#ABE8e is the most efficient adenine base editor? Read our paper with the amazing Audrey Lapinaite Nucleic Acids Res! The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency! academic.oup.com/nar/advance-ar…

#ncRNA molecules are stranger than you think. We propose that OLE RNA is bacteria's functional mimic of #mTOR. The Das lab at Stanford proposes OLE RNA penetrates cell membranes! They also find that RNAs we called ROOL and GOLLD form 8-membered nanocages. biorxiv.org/content/10.110…

Looking for a motivated Postdoctoral Fellow to join our team at UC Irvine! Contribute to cutting-edge research on developing innovative genome editors for treating ocular genetic diseases. #Postdoc #GenomeEditing #OcularResearch #UCI

New paper from our lab eLife - the journal. We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition. Enhanced flexibility improves the recognition of canonical and alternative PAM sequences. elifesciences.org/reviewed-prepr…

Dive into our lab’s first peer-reviewed publication—co-led with our friends Ben Adler and Muntathar Al-Shimary from the Doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s41564… Nature Microbiology

New study bioRxiv We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems! biorxiv.org/content/10.110… #GNN #StructuralBiology