How does tumor heterogeneity impact #metastasis? I am excited to share our latest pre-print: We used patient derived-xenograft models (PDX) of #breastcancer to examine the contributions of tumor heterogeneity on metastasis at single-cell resolution. doi.org/10.1101/2022.0… 1/n

Stupidity is important in scientific research. This is a very important message. Myself, I often say to students “You should know enough to start your research but never enough to know the outcome. Learn as you go.” ▫️ Prof. Martin Schwartz (Yale Univ.) discusses this in his

Thanks to all the participants and contributors of Aarhus Cancer Genomics Symposium Aarhus University events.au.dk/aarhuscancerge…. We had seven invited talks, ten short talks, and a fine collection of posters. I much enjoyed the interaction and the science. Dept. of Molecular Medicine #ACGS23

Applications open (due: Jan 10, 2024) for a 7-week undergraduate summer internship in mathematical oncology featuring classes, interdisciplinary research projects & hands-on tutorials. shorturl.at/arsR8 Plz RT Deepak Modi Abhijit Majumder Sutirth Dey Biopatrika ICGA Foundation

Our work on embryonic stem cell-derived mammary organoids has made it to the cover of today's Developmental Cell A visual narrative unfolds, showcasing the origin of mammary glands from hair-associated apocrine glands.@NCIResearchCtr @FredNatLab Xplainer (1/n)

Excited to organise a workshop on computational oncology with Dr Prashant K Srivastava at IIT Patna in April 2024. Register: iitp.ac.in/~wocon2024/ Speakers from industry & diverse academic disciplines Ramray Bhat Manjari Kiran Deeksha Bhartiya Mubasher Rashid Vibishan B | விபீஷண் பா. Rakesh Kumar Dheeraj Pandey

New preprint: "Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer" Although the concept of an evolutionary double-bind has long been hypothesized in cancer, it has not been measured. Kim Luddy (Kimberly Luddy) found one in our

#NewPaperAlert Thrilled to present our latest EMBO Reports paper demonstrating a strategy to induce stop codon readthrough in a transcript-selective manner using CRISPR-dCas13 bit.ly/LEMSME Lekha E M Anumeha Singh Sangeetha Devi Kumar Debaleena Kar IISc Bangalore The Biochemical Society

I’m pleased to announce my new paper, ‘Advice to a Young Mathematical Biologist’, published in the Bulletin of Mathematical Biology: doi.org/10.1007/s11538…. Fred Adler @HeikoEnderling Flasheff Louis Gross Mark Chaplain Sandy Anderson SMB - Society for Mathematical Biology Systems Modelling & Quantitative Biomedicine @IMSR_UoB

RCB forever ❤️

Glad to share work led by Sarthak Sahoo showing an increased prevalence of hybrid E/M state and higher heterogeneity in basal breast cancer, now out in iScience journal. Grateful to our collaborators Christine Chaffer @JSomarelli & Jyothi S Prabhu St. John's Research Institute #SJRI. sciencedirect.com/science/articl…

Thrilled to announce that I will be starting as an Assistant Professor and Curator at the University of Michigan in Jan 2025. My time will be split between UMich Ecology and Evolutionary Biology and UM Paleontology I will soon be looking for graduate students and postdocs. Please spread the word! 📣📣

At a recent conference Athena Aktipis invited me to give a talk on the role of creativity in science. For those interested here are the illustrated slides in tweetorial format. The take home message: Creativity and science go hand in hand. (Thread 1 of 2)

The final part of a 2 thread series on creativity in science (part 1 here: x.com/ATJCagan/statu…). Artists and scientists share common tools for thinking. However in the arts much more time is spent on developing these practices and techniques for creative problem solving.

Tumor heterogeneity is a major obstacle to effective cancer treatment. It is caused by multiple factors, including irreversible mutations and reversible phenotypic changes. But how can we model the interplay between both processes and what's their effect on cancer treatment? 1/

Excited to share this journal club article Nature Reviews Cancer discussing immunoproteasome as a new biomarker for immunotherapy. It covers the work of Kalaora et al., from Yardena Samuels's group and how it inspired new research in our lab National Centre for Biological Sciences 🔗rdcu.be/dW3c6

Excited to share our latest study in nature! We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! Shyam K. Sharan National Cancer Institute

New Preprint! Excited to share our latest work: "An integrative molecular systems approach unravels mechanisms underlying biphasic nitrate uptake by NRT1.1", in collaboration with Sarthak Sahoo Mubasher Rashid Mohit Kumar Jolly biorxiv.org/content/10.110…

I hate that it feels weird to post actual science on here now, given how much it feels like the country is sabotaging itself. But, our work on the Evolution of Evolvability is out! Huge congrats to Bhaskar, Alex Lalejini, and Mónica Acosta! pnas.org/doi/abs/10.107…