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Pericardial fat was associated with a statistically significant greater risk of heart failure after accounting for abdominal subcutaneous or visceral fat in a representative subsample of MESA (Multi-Ethnic Study of Atherosclerosis) participants.

Race and/or ethnicity did not alter the association between pericardial fat and the development of heart failure; the strength of the association was similar in White, Black, Hispanic, and Chinese Americans.

Biomarkers of inflammation (C-reactive protein and interleukin-6) and hemodynamic stress (N-terminal pro–B-type natriuretic peptide) did not attenuate the association between pericardial fat and newly diagnosed heart failure.

High compared with normal pericardial fat volume was associated with a higher cumulative incidence of Heart Failure with preserved, mid-range, and unknown ejection fraction (HFpEF, HFmrEF, and HFuEF) but not reduced Ejection Fraction (HFrEF).

Every one standard deviation (42 cm³) increase in pericardial fat volume (PFV) was associated with a 42% higher risk of Heart Failure with preserved Ejection Fraction (HFpEF). High compared with normal PFV conferred a 2.3-fold greater risk of HFpEF.

After adjustment for confounders, high pericardial fat volume was associated with a 40% higher risk of HFrEF that approached near statistical significance. On further adjustment for variables in the causal pathway, the residual 20% elevated risk was not statistically significant.

Despite small number of events, high compared with normal pericardial fat volume was modestly or borderline associated with a 2-fold greater risk of Heart Failure with mid-range Ejection Fraction (HFmrEF) and Heart Failure with unknown Ejection Fraction (HFuEF).

#PericardialFat and the risk of #HeartFailure Report by Ms. Lisa Drayer for CNN. cnn.com/2021/06/01/hea…

#PericardialFat and the risk of #HeartFailure Report by Ms. Fran Lowry for Medscape. medscape.com/viewarticle/95…

#PericardialFat and the risk of #HeartFailure Indexed in PubMed pubmed.ncbi.nlm.nih.gov/34045020/

#𝗣𝗲𝗿𝗶𝗰𝗮𝗿𝗱𝗶𝗮𝗹𝗙𝗮𝘁 𝗮𝗻𝗱 #𝗖𝗮𝗿𝗱𝗶𝗼𝗺𝘆𝗼𝗽𝗮𝘁𝗵𝘆 – 𝗘𝘅𝗽𝗲𝗿𝘁 𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 Published in the Pericardial Disease Clinical Topic Collection of the American College of Cardiology. acc.org/Latest-in-Card…

𝗖𝗼𝗺𝗽𝘂𝘁𝗲𝗱 𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝗶𝗰 𝗮𝗽𝗽𝗲𝗮𝗿𝗮𝗻𝗰𝗲 𝗼𝗳 #𝗣𝗲𝗿𝗶𝗰𝗮𝗿𝗱𝗶𝗮𝗹𝗙𝗮𝘁, which is a composite of #EpicardialFat located between the visceral pericardium and the myocardium and #ParacardialFat located external to the parietal pericardium.

ukbiobank.ac.uk/research-stori…