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This study shows mono- and combined #ICB (CICB) shared gut #microbiome features in response. In addition, Bacteroides intestinalis up-regulated mucosal IL-1b and correlated with colitis. Targeting IL-1b might uncouple the response from #irAEs using CICB. pubmed.ncbi.nlm.nih.gov/34239137/

Now online in Cancer Discovery: Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting #dysbiosis that contributes to carcinogenesis Satoru Yonekura, MD PhD @TerrisseSafae Carolina Alves Costa Silva, MD, PhD lisaderosa #LaurenceZitvogel Gustave Roussy Inserm cancerdiscovery.aacrjournals.org/content/early/…

#ICYMI: Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting #dysbiosis that contribute to carcinogenesis. Satoru Yonekura, MD PhD @TerrisseSafae Carolina Alves Costa Silva, MD, PhD lisaderosa Gustave Roussy Inserm Université Paris-Saclay #LaurenceZitvogel #ClinicObiome #microbiome

From the April issue: Cancer-induced ileopathy and #dysbiosis by Satoru Yonekura, MD PhD, @TerrisseSafae, Carolina Alves Costa Silva, MD, PhD, lisaderosa, #LaurenceZitvogel et al. bit.ly/3vr76Ug Gustave Roussy Inserm Université Paris-Saclay #ClinicObiome #Microbiome

Current Issue: Impact of Body Mass Index on Survival Outcomes of Patients with Metastatic Renal Cell Carcinoma in the Immuno-oncology Era: A Systematic Review and Meta-analysis buff.ly/3wkybHJ Satoru Yonekura, MD PhD Daniel Heng

What a pleasure to finally meet Jennifer Wargo MD , brilliant scientist and one of our greatest partners. Science is about sharing knowledge, effort and data. Let’s keep the pace, «the scoop is on the poop»!

What's your #dermatology #diagnosis? The patient responded to ustekinumab... ja.ma/3Ahc6gT via JAMA Dermatology part of JAMA Network #dermpath #dermtwitter #pathtwitter

Monkeypox #monkeypox #pathology #dermatology #dermpath

Patient who is a weight lifter and on an all protein diet. What has invaded the #brain on this #mri? #neurotwitter #meded #medtwitter #radtwitter

What's your diagnosis? Hint: first image at kikoxp.com/posts/14111 #dermatology #dermatologia #dermpath #dermtwitter

60 yo M. Multiple pruritic papules on trunk. Your diagnosis? Answer & video: kikoxp.com/posts/4316 #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter

75 yo man with erythematous scaly plaque on dorsal hand. Your diagnosis? What are the pretty pink swirling structures? Answers (& more pics) here: kikoxp.com/posts/8465. Video: kikoxp.com/posts/3771 #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

Brain metastases from #RCC treated with first-line therapies: results from the International Metastatic #RenalCellCarcinoma Database Consortium. Kosuke Takemura U Calgary joins Pedro C Barata, MD MSc FACP Case Comp Cancer Ctr in this discussion on UroToday > bit.ly/3GOJmhV

European, American and Asian researchers uniting over suchi and karaoke at #isid2023tokyo in beautiful #Japan. What a great conference!

Now in Science Magazine , Fidelle, Rauber, Carolina Alves Costa Silva, MD, PhD, Zitvogel, & al. show after #ABX treatment in mice, #Enterocloster recolonize gut → ↘️ MAdCAM-1. α4β7+ #Tr17Cells can then traffic from gut to #tumors & compromise #checkpoint #immunotherapy! bit.ly/Sci_abo2296

Science Magazine Carolina Alves Costa Silva, MD, PhD See also Feliu & al. in Science Immunology, which shows a positive role for gut-primed α4β7+ #CD8TCells against #ColonCancer #metastases in the mouse #liver! bit.ly/SciImm_adg8841

Science Magazine Carolina Alves Costa Silva, MD, PhD Science Immunology Finally, Brandon Pratt & Justin Milner put these two exciting papers in context with an outstanding Science Magazine Perspective! bit.ly/Sci_adi3357

New immune checkpoint affected by the gut #microbiome involved in lack of #immunotherapy responses in colon cancer. Read our double feature here: bit.ly/3NDvawe Virginie Feliu Devaud Christel AYYOUB LAB  Gustave Roussy  Carolina Alves Costa Silva, MD, PhD  lisaderosa #CRCSM