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So excited to present Blake Madruga 's amazing biorxiv paper on the first of our new generation of open-source 2-photon miniaturized microscopes. The scope has excellent resolution and great sensitivity such that we can image dendrites in RSC and image DG through an intact CA1.

Super excited to share our lab very first review highlighting resident tissue macrophages division of labor and its contribution to tissue/organ function beyond immunity. @jiazhao0 Ilya Andreev. MIT Biology @Ragoninstitute HHMI science.org/doi/10.1126/sc…

My lab in collaboration with Drs Mirzavand @ualberta & Ryait ULethbridge has few open positions in R&D initiatives concerning wireless systems that offer monitoring of behaviour and brain activity in humans and animals. Please retweet! rb.gy/2c3l87

📢 Epilepsy-linked Focal Cortical Dysplasia is due to somatic mutations in mTOR pathway genes🧬. Our study reveals cellular senescence in mutated neurons & senolytic drug efficacy in reducing seizures in mice🧟‍♀️ DOI: 10.1038/s41593-024-01634-2.

So thrilled that our paper on crystallization of working memory representations by practice is now published in Nature! Kudos to Arash Bellafard who with the Vaziri Lab imaged over 73K M2 neurons simultaneously during WM task performance and tracked neurons over days.

Congratulations Frederic Schaper and Michael Fox on this really cool work!

Fascinating work from Gilad Evrony and lab that brings us one step closer to understanding the mechanisms of double-strand DNA changes by surveying single strand DNA damage in health and disease.

Sara is brilliant, collaborative, highly productive, and generous…all the qualities that you need in a great mentor!

Thrilled to share this preprint on our study of somatic mutations in prion disease! Congrats to Gannon McDonough and Alana Cheng, a wonderful collaboration with August Yue Huang, Jiri Safar, ChrisAWalsh and others! Labor of love >7y in the making, finally out! #prion #genetics

Exciting new work by Janet Song , Taehwan Shin and Ryan Doan in ChrisAWalsh lab on functional contribution of non-coding variation to ASD. Many years in the making but well worth the wait!

A really great award for early career physician-scientists with out of the box ideas!

At the intersection of functional genomics and brain evolution Janet is THE expert and she is an awesome mentor!

Looking forward to catching up with friends Society for Neuroscience (SfN)! I am also looking for a postdoc trained in neurophys/systems neuro who is interested in modeling brain genetic mosaicism in neuronal cultures/mouse and combine with voltage imaging. Happy to meet at SFN to discuss! Plz RT.

Congratulations Diane Shao, MD, PhD !! Very well-deserved recognition.

If you are at #ASHG2024 and want to hear about our latest work on low level mosaicism in focal epilepsy, come by room 107 at 3 pm today. ASHG

Really important work by Alissa D’Gama and team Epilepsy Genetics Program illustrating the importance of a genome first approach in epilepsy genetic testing. IMO this has direct relevance for our adult patients with DEEs and syndromic epilepsies as well.

Amazing topic and even more amazing PI!

Very excited for #AES2024 to catch up with old friends and make new ones! My talented lab manager Ashton Tillett and I will be presenting two posters today at noon followed by presentations in Platform A. If you get excited about focal epilepsy genetics come talk to us!

Last night at the Basic Mechanisms SIG we talked about the molecular mechanisms of mosaic epilepsies. Join us tonight at the Genetics SIG to hear how genotype corresponds to clinical phenotype, paving the way for precision medicine American Epilepsy Society #AES2024

Thank you RASopathies Network for supporting our work! I am quite excited for this new research direction in my lab.