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About 10 years ago we had a crazy idea to put all the tRNA genes in the yeast genome onto a synthetic Neochromosome, and today we are able finally share with the world about this adventure. Manchester Institute of Biotechnology The University of Manchester

Thanks @JohnDoench Jolanda van Leeuwen Lea Starita and @LeopoldParts for the fantastic #CRISPR22 conference. One of the coolest conferences I've been to so far, with an outstanding selection of topics for #CRISPR functional genomics afficionados. Looking forward to the next one!

1/4 We are excited to open our postdoc #fellowship call for applications between EMBL & Stanford Medicine or Stanford H&S to enable collaboration & international training. stan.md/LSAfellows Show us your idea for bridging two leading institutions! 📅27 Jan 2023

Life Science Alliance EMBL Stanford Medicine Stanford H&S This is your chance for a unique postdoc opportunity. The postdoc call from Life Science Alliance is open. We’re looking forward seeing your ideas for your own project between 1 group from EMBL (any site) & 1 lab from Stanford Medicine OR Stanford H&S.

Thanks to Front Line Genomics for featuring image-enabled cells sorting (science.org/doi/10.1126/sc…) as a highlight in their 2022 report "Advances in single-cell and spatial analysis". Great summary of the field for current and future #SingleCell + #genomics aficionados.

We are looking for a talented researcher to join our Stanford Lab! We are a multidisciplinary and friendly group focussing on genomics & precision health. Get in touch for more details on the LSRP1 position. Please share with anyone who might be interested careersearch.stanford.edu/jobs/life-scie…

Check out our Commentary on novel technologies that combine cell sorting with #imaging. We highlight applications for #CRISPR functional genomics and multiomics readouts from single cells. Published today in Mol Syst Biol with Lars Steinmetz embopress.org/doi/full/10.15…

Commentary by Lars Steinmetz Daniel Schraivogel discusses the technical advancements made by image-enabled cell sorting & highlights new experimental strategies in #functionalgenomics & #singlecell research ➡️ bit.ly/3lyFeLv EMBL Stanford University

Interested in developing better genome editors using directed evolution? Apply for this 2-year postdoc position shared between @GenomePlant @PSB_VIB in Ghent and our group VIB-KU Leuven Center for Microbiology in Leuven, more details here: jobso.id/fqr7

We’re hiring! Fully funded postdoc position available in our group VIB-KU Leuven Center for Microbiology. Interested in developing highly multiplexed CRISPR/Cas-based tools for functional genomic screens in a non-model yeast? Please apply: jobso.id/g7sd

Image-enabled cell sorting (ICS) – a next-generation cell sorting method – is helping EMBL researchers gain new insights into cellular function in health and disease, as well as to explore other innovative applications. embl.org/news/science/t…

Hot off the press: Image-enabled cell sorting (science.org/doi/10.1126/sc…) applied to a heart disease model system identifies nothing less than a potential new therapeutic strategy to treat #DCM. Fantastic work led by Julia Kornienko from our lab.

At Dr. Lars Steinmetz's lab, scientists provide proof-of-principle for developing therapeutic strategies to restore RBM20’s nuclear localization in RBM20-dilated #cardiomyopathy patients. More in Nature Communications. 👉 go.nature.com/3pSiWa1

Planning CRISPR screens with single-cell readouts? Then you should have a look at our review of pooled CRISPR screens in single cells. Packed with practicalities for scRNA-seq and image-enabled cell sorting screens. With Lars Steinmetz and @LeopoldParts annualreviews.org/doi/abs/10.114…

Our latest preprint is out! In a fun collaboration with Anne Carpenter, PhD, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/8 biorxiv.org/content/10.110…

🔉Element Biosciences is coming to Heidelberg EMBL Join us on Wednesday, June 5th to discover new innovative products that enhance library prep efficiency and transform Element AVITI™ into a fully integrated biology system. Register now: bit.ly/4dXiEmb

We are very happy to share our preprint (D. Lindenhofer et al.) of a high-throughput targeted scDNA-scRNA-seq (SDR-seq) method. Impactful for any application with a need to associate coding and non-coding variants to gene expression in tissue samples and cell culture systems.

Been on a videos hiatus lately, in part bc we've been working hard to finish up our paper: We present a method called SDR-seq for targeted, simultaneous genotyping & expression measurement in single cells!

Fantastic postdoc opportunity in our lab at EMBL. Please apply or re-post ...

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇