Inhibiting PRDX6 to induce #ferroptosis may be a compelling target for #cancer therapy. Beautiful study from one of the most beautiful cities in the world, Kyoto. Profs Iwai and Fujita, thank you for elucidating this part of the cancer - ferroptosis link. nature.com/articles/s4159…

#Perspective #Featured #OpenAccess from Stuart Schreiber at Arena BioWorks Broad Institute: on proximity-inducing molecular glues and bifunctional compounds, drawing analogies to hot spots, missense mutations, and posttranslational mods dlvr.it/T8b5hQ

Cool story from Lei Lei Wu on Broad scientists that made a new, compact #epigenetic editing tool small enough to fit in an #AAV to tackle deadly prion disease. They did such a good job at making it small, the AAV expert told them to add some filler! endpts.com/to-tackle-a-de…

Polyglot Giulia Oliva speaks English, Greek, French, and her native Italian. She would love to learn more but is busy with another manner of translation—turning her splendido mind to generating insights in the lab that she hopes to translate to new ways of treating disease.

Hallmark of oncogenic mutant p53? Exceptionally high levels of expression. How to exploit for treating cancers? A bifunctional Chemical Inducer of Proximity (CIP) that targets a cytotoxic small molecule to mutant p53 cancers. See thread by William Gibson

Bravo Damian!

Proximity-inducing #molecularglues for RAS- and RAF-dependent cancers

Inspired by findings from Tanaz Sharifnia & Stuart Schreiber that GPX4 is essential in chordoma, we’ve demonstrated that GPX4 inhibition induces ferroptotic cell death, suggesting ferroptosis susceptibility may be a targetable vulnerability in chordoma. Results now on Figshare.

First-time dad Travis Blum knows that bringing something new into the world is hard, messy work, and about the most rewarding thing a person can do. He reaches beyond his job description to help in any way he can, his apologetic smile forever signaling regret for time's finitude.

Everybody gets angry. But don’t stay angry. Anger is counter-productive. Instead, be motivated by a desire to help others and . . . Love, Family, Country, Compassion, and Mastery. #PlayNiceButWin

Learning from the Generative AI community and exploring opportunities to interface with human biology at the Liquid AL Conference at MIT – a promising frontier

Howard Chang is a phenomenal choice for the CSO role at Amgen 🧪🔬🧬. Kudos to Jay Bradner, M.D. for shooting for the stars and recruiting a star scientist to his R&D leadership team. Together, they will transform science at Amgen 🧪🔬🧬.

PUFAs provide membrane fluidity and promote extravasation, but also result in vulnerability to a ferroptotic grease fire:

biorxiv.org/content/10.110… Compounds that recruit FKBP12 to novel targets with high cooperativity are the prototypical molecular glue and, represented by sirolimus and tacrolimus, have had major clinical impact. 1/3

Scientists create vast library of compounds to target disease proteins phys.org/news/2025-01-s…

Heartfelt congratulations, Jiaqi and Smriti, on this well-earned recognition. I'm proud to have my name associated with yours.

From Mike Maples, Jr in Pattern Breakers (quote from William Gibson): "The future is already here; it's just not evenly distributed." What's true of technology is true of medicine – we need insights into the inflection points to unlock transformative biotechs #SXSW2025

Under this ownership group, the Celtics won two championships and built a culture of camaraderie and resilience. Steve's deep loyalty to Boston makes him a champion both on and off the court, leaving a legacy that will forever inspire Celtics fans and Bostonians alike.

Outstanding Morgan Cheatham, MD NEJM AI

Excited to see this dynamic duo tackling high-impact biomedicine – among others, AI for reasoning on human evidence and AI for informed therapeutics forbes.com/sites/sindhyav…