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Very excited to be here in Florence for the #EuropeanPeptideSymposium2024 together with my colleagues Alejandro Yeste-Vázquez Marvin Albers juan lizandra perez and Jannik! Looking forward to all the interesting talks and insights!

Inspired by the success of proximity-based chimeras in both intracellular and extracellular target space, we describe LYsosome Membrane TArgeting Chimeras (LYMTACs) as a novel small molecule-based platform that functions intracellularly to modulate the membrane proteome.

Now as early view Angewandte Chemie: Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin doi.org/10.1002/anie.2… Big congrats to first author Alejandro Yeste-Vázquez & thanks to our great collaborators @Al_rebreG Hans Michael Maric Clemens Schulte #peptidomimetics

Suspension bead loading approach for the delivery of (synthetic)proteins into live cells is now in Angew Chem: onlinelibrary.wiley.com/doi/10.1002/an…

pressgazette.co.uk/social_media/n…

Excited to see our Synthesis Tag (SynTag) for the chemical synthesis of aggregating peptides and proteins out in J. Am. Chem. Soc.!! 🥳 pubs.acs.org/doi/10.1021/ja… Congratulation to first authors Héloïse Bürgisser and @elysetwilliams and everyone else involved UZH Chemistry UW–Madison Science

📣 Save the dates 📅 We are organizing a Benzon Symposium on "Protein structure prediction and design" with what I think is an amazing set of speakers Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and abstract submission will open in March

Just one more week to apply for the Novo Nordisk Golden Ticket, which provides lab bench and office space for one year at BioLabs Heidelberg or BioLabs Hôtel-Dieu (Paris), and access to the Novo Nordisk team of scientific and industry advisors biolabs.io/novo-nordisk-2…

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 nature.com/articles/s4146… (1/8) #ChemBio

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. Minhuan Li and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

Ukrainian journalist Viktoriia Roshchyna was imprisoned in Russia and never returned. Journalists traced her path and uncovered new evidence of Russian crimes. 1/6

🧬 Meet Lyra, a new paradigm for accessible, powerful modeling of biological sequences. Lyra is a lightweight SSM achieving SOTA performance across DNA, RNA, and protein tasks—yet up to 120,000x smaller than foundation models (ESM, Evo). Bonus: you can train it on your Mac. read

Main methods and tools for peptide development based on protein-protein interactions (PPIs) 1. This review offers a comprehensive framework for designing peptide therapeutics targeting protein-protein interactions (PPIs), emphasizing competitive peptides that mimic or block

Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at Ariax Bio to do the same thing.

Poxvirus targeted by RFdiffusion peptide-binders １．This study uses RFdiffusion to generate de novo peptide-binders that target the F13L protein of poxviruses—a key component in virus wrapping and the molecular target of the antiviral Tecovirimat. ２．F13L is a conserved

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AlphaFold modeling of polyubiquitin complexes and covalently linked proteins １．The paper presents two strategies for improving AlphaFold’s ability to model covalently linked ubiquitin chains and their complexes: one based on cysteine mutations and another using covalent

All-Atom Protein Sequence Design using Discrete Diffusion Models １．This paper presents the first application of discrete diffusion models to protein design using an all-atom representation. Instead of relying on the standard 20 amino acids, the authors use SELFIES to model