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Congratulations @drgauthi, collaborators Merck and our team for work out in Nature Chemistry showing functional group metathesis between in situ chlorinated carboxylic acids can offer a straightforward approach to carbon isotope labelling McGill Chemistry nature.com/articles/s4155…

Our third episode of the season is here! Check it out on your favorite platform or visit our show page at anchor.fm/pharm-to-table #MerckChemistry

With smart engineering techniques, we boosted ketoreductase activity for ipatasertib precursor synthesis by 64-fold. Algorithmic help shrunk library size, ensuring efficiency. Result? ≥98% conversion rate with 99.7% de!🌿🧪 👉rdcu.be/dzTZN Communications Chemistry NCCR Catalysis

Mentoring circles are back ✨ Don’t miss this awesome opportunity to network!

Exciting bioinformatics job opening in our department. jobs.merck.com/us/en/job/R284…

Was a pleasure to co-lead this year’s installment of the “Synthetic Approaches…” series! Check out the article here! Synthetic Approaches to the New Drugs Approved During 2022 | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.102…

Exciting news! I’m looking to hire a Senior Scientist to join our growing Discovery Process Chemistry group in London! 🇬🇧Same posting allows includes Discovery positions - double bonus! Application link below 👇👇 #MSDChemistry #UKChemJobs jobs.msd.com/gb/en/job/R285…

Great to see that Merck has taken interest in this DKR process that we discovered a few years ago. They also expanded the reaction scope to bulkier ncAAs and products with trans (2S,3S) configuration

Really great work by the team to avoid issues around byproduct removal associated with transaminases and develop lysine as a smart donor, plus a great scope of noncanonical branched arylalanines! #MerckChemistry Noah Dunham chemrxiv.org/engage/chemrxi…

Lysine - a new addition to the transaminase ‘smart’ amine donor collection! Check out the latest work from the Merck team! #merckchemistry #biocatalysis

Self-recycling imine reductases? Yes please! Congrats to the Novartis team for turning a promiscuous Glucose Dehydrogenase into an IRED #biocatalysis #proteinengineering #greenchemistry | ACS Catalysis pubs.acs.org/doi/10.1021/ac…

Excited that the final version of our work using lysine as a smart donor to prepare branched arylalanines is in J. Am. Chem. Soc. today! Amazing work by Noah Dunham and everyone who worked on this! #MerckChemistry RITWIKA RAY Matt Winston Yining Mikhail Reibarkh pubs.acs.org/doi/10.1021/ja…

Wild-type transaminases, a lysine smart donor, and a great scope of noncanonical amino acids, out today in J. Am. Chem. Soc. (pubs.acs.org/doi/10.1021/ja…). All thanks to a crack team! Steven Silverman, Matt Winston, RITWIKA RAY, Yining, Mikhail Reibarkh

📢 Calling all aspiring professionals! 🎙️ Jazzed for Merck to host #EWOC2024 so we’re preparing a special episode on 'How to Get a Job in Industry’ that will feature process and discovery hiring experts. 💼 Share your burning Q’s 👇👇and keep up the good work EWOC! 💪

Great talk from Kevin Maloney Merck on highly efficient, low-waste #enzyme cascade production of pharmaceuticals. #directedevolution #ECC9 #EuChemS2024 This is the sustainable future of #chemistry.

Thoroughly enjoyed the 2024 #Biocatalysis #GRC! Great job Sabine Flitsch and Carlos Martinez. Bring on the 2026 meeting with me and Dörte Rother as vice-chairs! Very excited to work with chairs Mélanie Hall and Radka Snajdrova as well as GRS chairs @hairofthehogg and Maximilian Gantz!

Check out our new work led by the amazing Dr. Ye Wang in J. Am. Chem. Soc.! We are so proud of this wonderful team and their investigation into the PLP radical! pubs.acs.org/doi/10.1021/ja…

Accelerating enzyme engineering: In Nature Chemical Biology we show that by removing destabilizing mutations from sequence space we generated a🚀Kemp eliminase in only 5 evolution cycles! Recombination charts the designer enzyme's fitness landscape🏔️. 👉nature.com/articles/s4158… NCCR Catalysis

Amazing news for the world of #proteins, #enzymes , #chemistry and #biocatalysis! Great day for science!

Congratulations to the seven 2025 ACS Pride Merck Graduate Research Award recipients! Read more here: tinyurl.com/MerckPROF Stay tuned for more information as the seven will speak at the 2025 ACS Spring Meeting in San Diego. #QueerInSTEM #STEMPride #ResearchExcellence #Award