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Really cool to see a CAR T cell-focused exhibit at The Franklin Institute Institute in Philly! Penn Medicine CHOP Research Carl June

The cover for our @BloodJournal article  “IL-18-secreting multiantigen targeting CAR T cells eliminate antigen-low myeloma in an immunocompetent mouse model” was selected as a finalist in the 2024 Blood Cover Contest! Please vote for us at a.cstmapp.com/p/989352 !

In an analysis of long term safety events in 783 patients treated with #Tcell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration analyses revealed no pathological insertions nature.com/articles/s4159…

🚨New paper alert! 🚨 Our latest work in Immunity shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/articl…

🚨Today in nature, we show that mRNA mis-splicing creates clonal public neoantigens in solid cancers. An amazing collaboration between UCSF Helen Diller Family Comprehensive Cancer Ctr and Memorial Sloan Kettering Cancer Center driven by Darwin Kwok and co-led by Hideho Okada, Joe Costello and Klebanoff_Lab. nature.com/articles/s4158…

🚨 Just out Nature Medicine! Introducing InflaMix—a point-of-care tool that identifies an #inflammatory 🔥 signature predictive of #CART failure in #lymphoma Led by Sandeep Raj (Sandeep Raj) 👏Memorial Sloan Kettering Cancer Center nature.com/articles/s4159… 🧵Let’s break it down